Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + tau protein-L-Thr434 | Homo sapiens | - |
ADP + [tau protein]-L-Thr434 phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + tau protein-L-Thr434 | - |
Homo sapiens | ADP + [tau protein]-L-Thr434 phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DYRK1A | - |
Homo sapiens |
minibrain kinase/dual-specificity tyrosine phosphorylated and regulated kinase 1A | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | there are higher levels of full-length DYRK1A in the brains of patients with Down syndrome when compared to control brains | up |
General Information | Comment | Organism |
---|---|---|
malfunction | overexpressed DYRK1A contributes to neurofibrillary degeneration in Down syndrome more significantly than in subjects with two copies of the DYRK1A gene and sporadic Alzheimers disease | Homo sapiens |