Cloned (Comment) | Organism |
---|---|
construction of His-tagged or GFP fusion proteins with the full length enzyme or enzyme fragments, expression in Dictyostelium discoideum cells | Dictyostelium discoideum |
Protein Variants | Comment | Organism |
---|---|---|
C800A | catalytic domain mutation, no remaining activity when expressed as full length enzyme or as catalytic domain only in a deficient Dictyostelium discoideum cell line | Dictyostelium discoideum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell cortex | - |
Dictyostelium discoideum | 5938 | - |
cytosol | - |
Dictyostelium discoideum | 5829 | - |
lamellipodium | - |
Dictyostelium discoideum | 30027 | - |
additional information | translocation of the enzyme within the cell responding to outer signals | Dictyostelium discoideum | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myosin II heavy chain | Dictyostelium discoideum | key role in regulating myosin localization | ADP + myosin II heavy chain phosphate | - |
? | |
ATP + myosin II heavy chain | Dictyostelium discoideum | the enzymes anterior localization is dynamically regulated during chemotaxis, phagocytosis, and other polarized cell motility events via direct binding to F-actin | ADP + myosin II heavy chain phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dictyostelium discoideum | P42527 | myosin II heavy chain kinase MHCK A | - |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged or GFP-fusion proteins from Dictyostelium discoideum | Dictyostelium discoideum |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + [myosin heavy-chain] = ADP + [myosin heavy-chain] phosphate | enzyme contains the C-terminal WD-domain, responsible for substrate binding, the catalytic domain, and the N-terminal coiled-coil translocation domain | Dictyostelium discoideum |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myosin heavy chain kinase | intramolecular autophosphorylation | Dictyostelium discoideum | ADP + myosin heavy chain kinase phosphate | - |
? | |
ATP + myosin II heavy chain | - |
Dictyostelium discoideum | ADP + myosin II heavy chain phosphate | - |
? | |
ATP + myosin II heavy chain | key role in regulating myosin localization | Dictyostelium discoideum | ADP + myosin II heavy chain phosphate | - |
? | |
ATP + myosin II heavy chain | the enzymes anterior localization is dynamically regulated during chemotaxis, phagocytosis, and other polarized cell motility events via direct binding to F-actin | Dictyostelium discoideum | ADP + myosin II heavy chain phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MHCK | - |
Dictyostelium discoideum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Dictyostelium discoideum |