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Information on EC 2.7.11.7 - myosin-heavy-chain kinase

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IUBMB Comments
The enzyme from Dictyostelium sp. (slime moulds) brings about phosphorylation of the heavy chains of Dictyostelium myosin, inhibiting the actin-activated ATPase activity of the myosin. One threonine residue in each heavy chain acts as acceptor. While the enzyme from some species is activated by actin, in other cases Ca2+/calmodulin are required for activity.
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The enzyme appears in viruses and cellular organisms
Synonyms
mhck a, mihck, myosin heavy chain kinase, a-cat, mhck b, mihc kinase, myosin heavy chain kinase a, mhck-b, myosin ii heavy chain kinase, myosin ii heavy chain kinase a, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
ATP + [myosin heavy-chain] = ADP + [myosin heavy-chain] phosphate
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