Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxoisocaproate | - |
Bos taurus | |
3-methyl-2-oxobutanoate | - |
Bos taurus | |
4-methyl-2-oxopentanoate | - |
Bos taurus | |
ADP | - |
Bos taurus | |
branched-chain 2-oxo acids | - |
Bos taurus | |
diphosphate | - |
Bos taurus | |
MgATP2- | - |
Bos taurus | |
additional information | no inhibition by acetyl-CoA; no inhibition by coenzyme A | Bos taurus | |
thiamine | - |
Bos taurus | |
thiamine diphosphate | - |
Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0126 | - |
ATP | pH 7.5, 30°C | Bos taurus | |
0.0126 | - |
ATP | ATP in form of MgATP2- | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Bos taurus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requirement, actual substrate: MgATP2- | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | Bos taurus | phosphorylation inactivates EC 1.2.4.4 | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] | - |
Bos taurus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate | - |
? | |
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | phosphorylates alpha-subunit of multienzyme complex component E1 | Bos taurus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | Ser-residues of MW 46000-subunit | Bos taurus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | phosphorylation inactivates EC 1.2.4.4 | Bos taurus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Bos taurus |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
7 | - |
loss of activity during purification at pH-values below 7 | Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00027 | - |
ADP | pH 7.5, 30°C | Bos taurus | |
0.00048 | - |
4-methyl-2-oxopentanoate | pH 7.5, 30°C | Bos taurus | |
0.00092 | - |
2-oxoisocaproate | pH 7.5, 30°C | Bos taurus | |
0.004 | - |
diphosphate | pH 7.5, 30°C | Bos taurus | |
0.0059 | - |
thiamine | pH 7.5, 30°C | Bos taurus | |
0.0089 | - |
4-methyl-2-oxopentanoate | pH 7.5, 30°C | Bos taurus |