Inhibitors | Comment | Organism | Structure |
---|---|---|---|
compound C | a specific inhibitor of AMPK | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13131 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
heterotrimer | enzyme AMPK is composed of AMPKalpha, beta and gamma subunits | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
5'-AMP-activated protein kinase | - |
Homo sapiens |
AMPK | - |
Homo sapiens |
AMPKalpha | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | stabilization of MAPO1 occurs in AMPKalpha-knockdown cells even without N-methyl-N-nitrosourea treatment. Knockdown of the Flcn and Ampkalpha genes by specific siRNAs significantly suppresses an apoptotic response to N-methyl-N-nitrosourea | Homo sapiens |
physiological function | AMPK is a cellular energy sensor that negatively regulates cell growth and proliferation. MAPO1, identified as a component involved in the induction of apoptosis, is stabilized by interaction with AMP-activated protein kinase (AMPK) and folliculin (FLCN). AMPK is activated during the process of O6-methylguanine-induced apoptosis and this activation is dependent on MAPO1 and folliculin. It is likely that the kinase activity of AMPK is involved in the degradation of MAPO1 | Homo sapiens |