Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside | i.e. AICAR | Homo sapiens | |
AMP | - |
Homo sapiens | |
additional information | the enzyme is activated by phosphorylation at Thr172 in the alpha subunit activation T-loop | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
transient expression of wild-type and mutant enzymes in COS-7 cells, co-expression with histone deacetylase 5 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K45R | a dominant negative AMPK mutant | Homo sapiens |
T172D | a constitutively active AMPK mutant | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [histone deacetylase 5] | Homo sapiens | AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5 | ADP + [histone deacetylase 5] phosphate | - |
? | |
additional information | Homo sapiens | AMPK is activated in response to changes in the cellular energy charge and cellular stress via increases in the ATP-to-AMP ratio | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the enzyme is activated by phosphorylation at Thr172 in the alpha subunit activation T-loop | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
myotube | primary | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [histone deacetylase 5] | AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5 | Homo sapiens | ADP + [histone deacetylase 5] phosphate | - |
? | |
ATP + [histone deacetylase 5] | phosphorylation at Ser259 and Ser498 | Homo sapiens | ADP + [histone deacetylase 5] phosphate | - |
? | |
additional information | AMPK is activated in response to changes in the cellular energy charge and cellular stress via increases in the ATP-to-AMP ratio | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
trimer | alphabetagamma heterotrimer composed of different alpha, beta, and gamma subunit variants | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
AMP-activated protein kinase | - |
Homo sapiens |
AMPK | - |
Homo sapiens |
HDAC5 kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |