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Literature summary for 2.7.11.29 extracted from
- Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II (1987), J. Biol. Chem., 262, 1344-1351.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no activation by polylysine | Bos taurus |
General Stability
| General Stability | Organism |
|---|---|
| high salt concentrations, e.g. 1 mM NaCl, inactivate | Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| heparin | strong | Bos taurus |  |
| Low-density lipoprotein receptor | above 10 nM, spermine protects | Bos taurus | |
| additional information | no inhibition by cAMP, cGMP, Ca2+/calmodulin, Ca2+/phosphatidylserine or N-ethylmaleimide | Bos taurus | |
| polylysine | strong | Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000005 | - |
Low-density lipoprotein receptor | 30°C, pH 7.5 | Bos taurus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Bos taurus | 5829 | - |
| soluble | - |
Bos taurus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + low-density lipoprotein receptor | Bos taurus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | cortex | Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0033 | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + casein | - |
Bos taurus | ? | - |
? | |
| ATP + low-density lipoprotein receptor | - |
Bos taurus | ? | - |
? | |
| ATP + low-density lipoprotein-L-serine | phosphorylates the Ser-833 in the cytoplasmic domain of the low-density lipoprotein receptor | Bos taurus | ADP + low-density lipoprotein O-phospho-L-serine | - |
? | |
| ATP + low-density lipoprotein-L-serine | GTP can replace ATP to some extent | Bos taurus | ADP + low-density lipoprotein O-phospho-L-serine | - |
? | |
| ATP + low-density lipoprotein-L-serine | no substrates are protamine or histamine | Bos taurus | ADP + low-density lipoprotein O-phospho-L-serine | - |
? | |
| ATP + phosvitin | - |
Bos taurus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Bos taurus |
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Release 2023.1 (January 2023)
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