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Information on EC 2.7.11.29 - low-density-lipoprotein receptor kinase for references in articles please use BRENDA:EC2.7.11.29
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EC Tree
IUBMB Comments Phosphorylates the last serine residue (Ser-833) in the cytoplasmic domain of the low-density lipoprotein receptor from bovine adrenal cortex. Casein can also act as a substrate but with lower affinity. GTP can act instead of ATP.
The expected taxonomic range for this enzyme is: Bos taurus
Synonyms
LDL receptor kinase, low-density lipoprotein receptor kinase, low-density-lipoprotein receptor kinase (phosphorylating),
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LDL receptor kinase
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low-density lipoprotein receptor kinase
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low-density-lipoprotein receptor kinase (phosphorylating)
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ATP + [low-density-lipoprotein receptor]-L-serine = ADP + [low-density-lipoprotein receptor]-O-phospho-L-serine
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phospho group transfer
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ATP:[low-density-lipoprotein receptor]-L-serine O-phosphotransferase
Phosphorylates the last serine residue (Ser-833) in the cytoplasmic domain of the low-density lipoprotein receptor from bovine adrenal cortex. Casein can also act as a substrate but with lower affinity. GTP can act instead of ATP.
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ATP + low-density lipoprotein receptor
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ATP + low-density lipoprotein-L-serine
ADP + low-density lipoprotein O-phospho-L-serine
ATP + phosvitin
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ATP + tubulin
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ATP + casein
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ATP + casein
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phosphorylated by catalytic subunit, activator subunit not required
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ATP + low-density lipoprotein-L-serine
ADP + low-density lipoprotein O-phospho-L-serine
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phosphorylates the Ser-833 in the cytoplasmic domain of the low-density lipoprotein receptor
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ATP + low-density lipoprotein-L-serine
ADP + low-density lipoprotein O-phospho-L-serine
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enzyme is composed of a catalytic and an activator subunit, the specificity for low-density lipoprotein receptor is attributable to the latter
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ATP + low-density lipoprotein-L-serine
ADP + low-density lipoprotein O-phospho-L-serine
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GTP can replace ATP to some extent
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ATP + low-density lipoprotein-L-serine
ADP + low-density lipoprotein O-phospho-L-serine
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no substrates are protamine or histamine
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ATP + low-density lipoprotein receptor
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Low-density lipoprotein receptor
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above 10 nM, spermine protects
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Trypsin
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inactivation of activator subunit
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additional information
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no inhibition by cAMP, cGMP, Ca2+/calmodulin, Ca2+/phosphatidylserine or N-ethylmaleimide
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additional information
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no activation by polylysine
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0.000005
Low-density lipoprotein receptor
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30°C, pH 7.5
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0.00118
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casein as substrate
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brenda
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cortex
brenda
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brenda
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brenda
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120000
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alphabeta, 1 * 35000-50000 + 1 * 120000, SDS-PAGE and gel filtration, a catalytic subunit for phosphorylation and an activator subunit, activator subunit not required
155000 - 170000
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gel filtration
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dimer
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dimer
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alphabeta, 1 * 35000-50000 + 1 * 120000, SDS-PAGE and gel filtration, a catalytic subunit for phosphorylation and an activator subunit, activator subunit not required
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high salt concentrations, e.g. 1 mM NaCl, inactivate
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Kishimoto, A.; Brown, M.S.; Slaughter, C.A.; Goldstein, J.L.
Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II
J. Biol. Chem.
262
1344-1351
1987
Bos taurus
brenda
Kishimoto, A.; Goldstein, J.L.; Brown, M.S.
Purification of catalytic subunit of low density lipoprotein receptor kinase and identification of heat-stable activator protein
J. Biol. Chem.
262
9367-9373
1987
Bos taurus
brenda
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