We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Information on EC 2.7.11.29 - low-density-lipoprotein receptor kinase for references in articles please use BRENDA:EC2.7.11.29
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments Phosphorylates the last serine residue (Ser-833) in the cytoplasmic domain of the low-density lipoprotein receptor from bovine adrenal cortex. Casein can also act as a substrate but with lower affinity. GTP can act instead of ATP.
The expected taxonomic range for this enzyme is: Bos taurus
Synonyms
LDL receptor kinase, low-density lipoprotein receptor kinase, low-density-lipoprotein receptor kinase (phosphorylating),
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
LDL receptor kinase
-
-
-
-
low-density lipoprotein receptor kinase
-
-
-
-
low-density-lipoprotein receptor kinase (phosphorylating)
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + [low-density-lipoprotein receptor]-L-serine = ADP + [low-density-lipoprotein receptor]-O-phospho-L-serine
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
phospho group transfer
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP:[low-density-lipoprotein receptor]-L-serine O-phosphotransferase
Phosphorylates the last serine residue (Ser-833) in the cytoplasmic domain of the low-density lipoprotein receptor from bovine adrenal cortex. Casein can also act as a substrate but with lower affinity. GTP can act instead of ATP.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + low-density lipoprotein receptor
?
-
-
-
-
?
ATP + low-density lipoprotein-L-serine
ADP + low-density lipoprotein O-phospho-L-serine
ATP + phosvitin
?
-
-
-
-
?
ATP + tubulin
?
-
-
-
-
?
ATP + casein
?
-
-
-
-
-
ATP + casein
?
-
phosphorylated by catalytic subunit, activator subunit not required
-
-
-
ATP + low-density lipoprotein-L-serine
ADP + low-density lipoprotein O-phospho-L-serine
-
phosphorylates the Ser-833 in the cytoplasmic domain of the low-density lipoprotein receptor
-
?
ATP + low-density lipoprotein-L-serine
ADP + low-density lipoprotein O-phospho-L-serine
-
enzyme is composed of a catalytic and an activator subunit, the specificity for low-density lipoprotein receptor is attributable to the latter
-
?
ATP + low-density lipoprotein-L-serine
ADP + low-density lipoprotein O-phospho-L-serine
-
GTP can replace ATP to some extent
-
?
ATP + low-density lipoprotein-L-serine
ADP + low-density lipoprotein O-phospho-L-serine
-
no substrates are protamine or histamine
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + low-density lipoprotein receptor
?
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Low-density lipoprotein receptor
-
above 10 nM, spermine protects
-
Trypsin
-
inactivation of activator subunit
-
additional information
-
no inhibition by cAMP, cGMP, Ca2+/calmodulin, Ca2+/phosphatidylserine or N-ethylmaleimide
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
-
no activation by polylysine
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.000005
Low-density lipoprotein receptor
-
30°C, pH 7.5
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.00118
-
casein as substrate
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
cortex
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
120000
-
alphabeta, 1 * 35000-50000 + 1 * 120000, SDS-PAGE and gel filtration, a catalytic subunit for phosphorylation and an activator subunit, activator subunit not required
155000 - 170000
-
gel filtration
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
dimer
-
-
dimer
-
alphabeta, 1 * 35000-50000 + 1 * 120000, SDS-PAGE and gel filtration, a catalytic subunit for phosphorylation and an activator subunit, activator subunit not required
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
high salt concentrations, e.g. 1 mM NaCl, inactivate
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Kishimoto, A.; Brown, M.S.; Slaughter, C.A.; Goldstein, J.L.
Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II
J. Biol. Chem.
262
1344-1351
1987
Bos taurus
brenda
Kishimoto, A.; Goldstein, J.L.; Brown, M.S.
Purification of catalytic subunit of low density lipoprotein receptor kinase and identification of heat-stable activator protein
J. Biol. Chem.
262
9367-9373
1987
Bos taurus
brenda
Select items on the left to see more content.
html completed
HOME
login
history
all enzymes
BRENDA home
History
2.7.11.29 low-density-lipoprotein receptor kinase
more
top
Information
