Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.26 extracted from

  • Cortes-Gomez, M.; Llorens-Alvarez, E.; Alom, J.; del Ser, T.; Avila, J.; Saez-Valero, J.; Garcia-Ayllon, M.
    Tau phosphorylation by glycogen synthase kinase 3beta modulates enzyme acetylcholinesterase expression (2020), J. Neurochem., 157, 2091-2105 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.26

Protein Variants

Protein Variants Comment Organism
K85A kinase-dead mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
SB216763
-
 Homo sapiens
tideglusib irreversible inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + tau-protein Homo sapiens
-
 ADP + O-phospho-tau-protein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P49841
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuroblastoma cell
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + tau-protein
-
 Homo sapiens ADP + O-phospho-tau-protein
-
 ?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase 3beta
-
 Homo sapiens
GSK3beta
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function over-expression the enzyme and tau-protein provokes an imbalance in cholinergic activity with a decrease in the neurotransmitter acetylcholine in the cell. An increased phosphorylation of tau by the kinase GSK3beta can modulate the levels of the cholinergic acetylcholinesterase. These changes may consequently compromise cholinergic neurotransmission Homo sapiens