Literature summary for 2.7.11.26 extracted from

Jana, S.; Singh, S.K.
Identification of human tau-tubulin kinase 1 inhibitors an integrated e-pharmacophore-based virtual screening and molecular dynamics simulation (2020), J. Biomol. Struct. Dyn., 38, 886-900 .

Search for more literature for 2.7.11.26

Inhibitors

Inhibitors	Comment	Organism	Structure
(2S)-3-cyclohexyl-2-(9H-purin-6-ylamino)propan-1-ol	ZINC00012956	Homo sapiens
1-[3-(6-amino-9H-purin-9-yl)propyl]-3-methylpyridin-2(1H)-one	ZINC91332506	Homo sapiens
3-[5-[((4-amino-4-methylpiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino)-5-bromophenol	-	Homo sapiens
4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	-	Homo sapiens
5,6-dihydroxy-2-(4-hydroxy-3-methoxycyclohexa-1,5-dien-1-yl)-7-methoxy-4H-chromen-4-one	ZINC14644839	Homo sapiens
methyl 2-bromo-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzoate	-	Homo sapiens
N-(4-ethoxy-3-fluorobenzyl)-9H-purin-6-amine	ZINC69775110	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + tau-protein	Homo sapiens	phosphorylation on Ser198, Ser199, Ser202, and Ser422	ADP + O-phospho-tau-protein	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q5TCY1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + tau-protein	phosphorylation on Ser198, Ser199, Ser202, and Ser422	Homo sapiens	ADP + O-phospho-tau-protein	-	?

Synonyms

Synonyms	Comment	Organism
Tau-tubulin kinase 1	-	Homo sapiens
TTBK1	isoform	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	phosphorylation of isoform TTBK1 is linked to neurodegenerative diseases like Alzheimer's disease, amyotrophic lateral sclerosis, and spinocerebellar ataxia type 11	Homo sapiens

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Release 2023.1 (January 2023)