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Literature summary for 2.7.11.26 extracted from

  • Fernius, J.; Starkenberg, A.; Pokrzywa, M.; Thor, S.
    Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau (2017), Biol. Open, 6, 113-1023 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + tau-protein Drosophila melanogaster phosphorylation at Ser-422 ADP + O-phospho-tau-protein
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + tau-protein phosphorylation at Ser-422 Drosophila melanogaster ADP + O-phospho-tau-protein
-
 ?

Subunits

Subunits Comment Organism
? x * 180000, isoform TTBK1, SDS-PAGE Drosophila melanogaster
? x * 180000, isoform TTBK2, SDS-PAGE Drosophila melanogaster
? x * 200000, isoform MARK1, SDS-PAGE Drosophila melanogaster

Synonyms

Synonyms Comment Organism
MARK1
-
 Drosophila melanogaster
Tau tubulin binding kinase1
-
 Drosophila melanogaster
Tau tubulin binding kinase2
-
 Drosophila melanogaster
Tau-kinase
-
 Drosophila melanogaster
TTBK1
-
 Drosophila melanogaster
TTBK2
-
 Drosophila melanogaster

General Information

General Information Comment Organism
physiological function the tau-kinases MARK1, TTBK1, TTBK2 reduce lifespan of Drosophila melanogaster, and the effects are increased by co expression with human tau-protein Drosophila melanogaster