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Literature summary for 2.7.11.23 extracted from

  • Wilcox, C.B.; Rossettini, A.; Hanes, S.D.
    Genetic interactions with C-terminal domain (CTD) kinases and the CTD of RNA Pol II suggest a role for ESS1 in transcription initiation and elongation in Saccharomyces cerevisiae (2004), Genetics, 167, 93-105.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.23

Cloned(Commentary)

Cloned (Comment) Organism
analysis of genetic interaction between ESS1 and CTD kinase genes, overexpression of wild-type and mutant CTD kinases Ctk1, Bur1, Kin28, and Srb10 in wild-type or mutant yeast strains, the latter being deficient in enzyme activity or in Ess1, overview Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
D324N inactive Ctk1 mutant Saccharomyces cerevisiae
additional information construction of several enzyme-deficient disruption mutant strains, overview, CTK1 can rescue the growth defects of an Ess1-deficient mutant at low concentration, but enhances the defects if overexpressed Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Saccharomyces cerevisiae 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [DNA-directed RNA polymerase] Saccharomyces cerevisiae the CTD kinases Ctk1, Bur1, Kin28, and Srb10 are involved in preinitiation of transcription and elongation ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
additional information Saccharomyces cerevisiae CTD kinase function is opposed by Ess1, an essential prolyl isomerase binding to the C-terminal domain of the RNA polymerase, Ess1 interacts with CTD kinases, especially with Ctk1 and Srb10, the kinase and Ess1 compete for Ser5 of RNA polymerase II ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [DNA-directed RNA polymerase] the CTD kinases Ctk1, Bur1, Kin28, and Srb10 are involved in preinitiation of transcription and elongation Saccharomyces cerevisiae ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
ATP + [DNA-directed RNA polymerase] the enzyme phosphorylates the C-terminal CTD domain of the RNA polymerase II large subunit Saccharomyces cerevisiae ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
additional information CTD kinase function is opposed by Ess1, an essential prolyl isomerase binding to the C-terminal domain of the RNA polymerase, Ess1 interacts with CTD kinases, especially with Ctk1 and Srb10, the kinase and Ess1 compete for Ser5 of RNA polymerase II Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
Bur1
-
 Saccharomyces cerevisiae
C-terminal domain kinase
-
 Saccharomyces cerevisiae
CTD kinase
-
 Saccharomyces cerevisiae
Ctk1
-
 Saccharomyces cerevisiae
Kin28
-
 Saccharomyces cerevisiae
Srb10
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Saccharomyces cerevisiae