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Literature summary for 2.7.11.20 extracted from

  • Wang, Y.; Huang, G.; Wang, Z.; Qin, H.; Mo, B.; Wang, C.
    Elongation factor-2 kinase acts downstream of p38 MAPK to regulate proliferation, apoptosis and autophagy in human lung fibroblasts (2018), Exp. Cell Res., 363, 291-298 .
    View publication on PubMed
Search for more literature for 2.7.11.20

Inhibitors

Inhibitors Comment Organism Structure
A-484954
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [elongation factor 2] Homo sapiens
-
 ADP + [elongation factor 2] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung fibroblast
-
 Homo sapiens
-
MRC-5 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [elongation factor 2]
-
 Homo sapiens ADP + [elongation factor 2] phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 95000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
eEF2 kinase
-
 Homo sapiens
eEF2K
-
 Homo sapiens
elongation factor-2 kinase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction inhibition of the enzyme markedly augments cell proliferation and differentiation, suppresses apoptosis and autophagy, and reverses the anti-fibrotic effects of a p38 MAPK inhibitor. Enzyme inhibition induces resistance to apoptosis in MRC-5 cells treated with transforming growth factor beta 1 Homo sapiens
physiological function the enzyme acts downstream of p38 MAPK to regulate proliferation, apoptosis and autophagy in human lung fibroblasts. The enzyme might inhibit transforming growth factor beta 1-induced NHLF proliferation and differentiation and activates normal lung fibroblast cell apoptosis and autophagy through p38 MAPK signaling, which might ameliorate lung fibroblast-to-myofibroblast differentiation Homo sapiens