Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphorylated MEK | activates the enzyme | Homo sapiens | |
phosphorylated p70S6K | activates the enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [elongation translation factor 2] | Homo sapiens | - |
ADP + [elongation translation factor 2]phosphate | - |
? | |
additional information | Homo sapiens | SCH66336, a farnesyltransferase inhibitor, induces rapid phosphorylation and inhibition of eukaryotic translation elongation factor 2 in head and squamous cell carcinoma cells leading to growth inhibition in the cancer cells, the inhibitor functions independently of the signaling cascade involving the eEF2 kinase and its activators phosphorylated p70S6K and phosphorylated MEK | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MDA-1186 cell | cancer cell line | Homo sapiens | - |
MDA-886 cell | cancer cell line | Homo sapiens | - |
squamous cell carcinoma cell | cell lines of head and neck cancer | Homo sapiens | - |
TR-146 cell | cancer cell line | Homo sapiens | - |
UMSCC-14B cell | cancer cell line | Homo sapiens | - |
UMSCC-17B cell | cancer cell line | Homo sapiens | - |
UMSCC-21A cell | cancer cell line | Homo sapiens | - |
UMSCC-22A cell | cancer cell line | Homo sapiens | - |
UMSCC-38 cell | cancer cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [elongation translation factor 2] | - |
Homo sapiens | ADP + [elongation translation factor 2]phosphate | - |
? | |
additional information | SCH66336, a farnesyltransferase inhibitor, induces rapid phosphorylation and inhibition of eukaryotic translation elongation factor 2 in head and squamous cell carcinoma cells leading to growth inhibition in the cancer cells, the inhibitor functions independently of the signaling cascade involving the eEF2 kinase and its activators phosphorylated p70S6K and phosphorylated MEK | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
eEF2 kinase | - |
Homo sapiens |
eEF2K | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |