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Literature summary for 2.7.11.18 extracted from

  • Wang, T.; Mathew, B.; Wu, X.; Shimizu, Y.; Rizzo, A.N.; Dudek, S.M.; Weichselbaum, R.R.; Jacobson, J.R.; Hecker, L.; Garcia, J.G.
    Nonmuscle myosin light chain kinase activity modulates radiation-induced lung injury (2016), Pulm. Circ., 6, 234-239 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.18

Inhibitors

Inhibitors Comment Organism Structure
1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride
-
 Mus musculus
RKKYKYRRK-NH2 highly specific peptide inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [myosin light chain] Mus musculus
-
 ADP + [myosin light chain] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [myosin light chain]
-
 Mus musculus ADP + [myosin light chain] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
nmMLCK
-
 Mus musculus
nonmuscle myosin light chain kinase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus thoracic irradiation significantly augments protein expression and enzymatic activity of the nonmuscle isoform of myosin light chain kinase up

General Information

General Information Comment Organism
malfunction mice harboring a deletion of the nmMLCK gene exhibit protection from radiation-induced lung injury, as assessed by attenuated vascular leakage and leukocyte infiltration Mus musculus
physiological function the nonmuscle myosin light chain kinase plays a key role in vascular barrier regulation in radiation-induced lung injury Mus musculus