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Literature summary for 2.7.11.18 extracted from

  • Kemp, B.E.; Parker, M.W.; Hu, S.; Tiganis, T.; House, C.
    Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity (1994), Trends Biochem. Sci., 19, 440-444.
    View publication on PubMed
Search for more literature for 2.7.11.18

Activating Compound

Activating Compound Comment Organism Structure
additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia

Crystallization (Commentary)

Crystallization (Comment) Organism
twitchin kinase, bilobal structure analysis Mammalia

Inhibitors

Inhibitors Comment Organism Structure
additional information the enzyme is inhibited by its regulatory subunit masking the active site, autoregulation by a pseudosubstrate mechanism, protein substrate-pseudosubstrate interactions, overview Mammalia
protein kinase inhibitor PKI
-
 Mammalia

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + myosin light chain Mammalia
-
 ADP + phosphorylated myosin light chain
-
 ?

Organism

Organism UniProt Comment Textmining
Mammalia
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Mammalia
-
smooth muscle
-
 Mammalia
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + myosin light chain
-
 Mammalia ADP + phosphorylated myosin light chain
-
 ?
additional information substrate specificity and binding structure, the enzyme depends on basic residues for substrate recognition, autoregulation by a pseudosubstrate mechanism, overview Mammalia ?
-
 ?

Synonyms

Synonyms Comment Organism
MLCK
-
 Mammalia
Twitchin kinase
-
 Mammalia

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mammalia