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Literature summary for 2.7.11.14 extracted from
- Rhodopsin kinase activity modulates the amplitude of the visual response in Drosophila (2004), Proc. Natl. Acad. Sci. USA, 101, 11874-11879.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| G-protein | dependent on | Drosophila melanogaster |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression of myc-tagged wild-type and K220R mutant enzyme fused to heat shock inducible promotors in photoreceptor cells of flies, cells overexpressing the wild-type enzyme show increased phosphorhodopsin content after heat shock activation | Drosophila melanogaster |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K220R | site-directed mutagenesis, ATP binding site mutation, inactive mutant | Drosophila melanogaster |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Drosophila melanogaster | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Drosophila melanogaster |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + rhodopsin 1 | Drosophila melanogaster | - |
ADP + phosphorhodopsin 1 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
gene gprk1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| eye | adult | Drosophila melanogaster | - |
| head | - |
Drosophila melanogaster | - |
| photoreceptor | most GPRK1 in the eye | Drosophila melanogaster | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
assay at dark | Drosophila melanogaster |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + rhodopsin 1 | - |
Drosophila melanogaster | ADP + phosphorhodopsin 1 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| G-protein coupled receptor kinase | - |
Drosophila melanogaster |
| GPRK1 | - |
Drosophila melanogaster |
| GRK1 | - |
Drosophila melanogaster |
| GRK7 | - |
Drosophila melanogaster |
| RK | - |
Drosophila melanogaster |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Drosophila melanogaster |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Drosophila melanogaster |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Drosophila melanogaster | |
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