Activating Compound | Comment | Organism | Structure |
---|---|---|---|
4beta-phorbol 12-myristate 13-acetate | - |
Homo sapiens | |
additional information | PKC activation can inhibit zinc transporter ZIP8 activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GF 109203X | broad-spectrum PKC inhibitor | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cd2+ | cell exposure to 0.020 mM cadmium for 24 h results in PKC activation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + extracellular signal-related kinase | - |
Homo sapiens | ADP + phosphorylated extracellular signal-related kinase | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKC | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | prolonged PKC activation by phorbol esters is downregulates PKC for at least 24 h | down |
General Information | Comment | Organism |
---|---|---|
physiological function | PKC plays a protective role in cells exposed to cadmium, as its early activation by 4beta-phorbol 12-myristate 13-acetate reduces both delayed extracellular signal-related kinase activation and cadmium toxicity, whereas blocking its activity has the opposite effect | Homo sapiens |