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Literature summary for 2.7.11.12 extracted from

  • Ramdani, G.; Schall, N.; Kalyanaraman, H.; Wahwah, N.; Moheize, S.; Lee, J.J.; Sah, R.L.; Pfeifer, A.; Casteel, D.E.; Pilz, R.B.
    cGMP-dependent protein kinase-2 regulates bone mass and prevents diabetic bone loss (2018), J. Endocrinol., 238, 203-219 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
cGMP
-
 Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mus musculus Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
R242Q the partially activated mutant enzyme expressed in primary osteoblasts of transgenic mice shows a 2-3fold increase in basal and total isoform PKG2 activity; they proliferate faster and are resistant to apoptosis compared to cells from wild type mice Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
osteoblast
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GRRESLTSFG
-
 Rattus norvegicus ADP + phosphorylated GRRESLTSFG
-
 ?
ATP + VASP protein
-
 Rattus norvegicus ADP + phosphorylated VASP protein
-
 ?

Subunits

Subunits Comment Organism
? x * 70000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
cGMP-dependent protein kinase type 2
-
 Rattus norvegicus
cGMP-dependent protein kinase-2
-
 Rattus norvegicus
PKG2 isoform Rattus norvegicus

General Information

General Information Comment Organism
physiological function isoform PKG2 is a key regulator of osteoblast proliferation and post-natal bone formation Rattus norvegicus