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Literature summary for 2.7.11.12 extracted from
- Distinct functions of a cGMP-dependent protein kinase in nerve terminal growth and synaptic vesicle cycling (2019), J. Cell Sci., 132, jcs227165 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neuron | - |
Drosophila melanogaster | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FOR | - |
Drosophila melanogaster |
| PKG | - |
Drosophila melanogaster |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the presynaptic, but not postsynaptic or glial, enzyme gene is required for synaptic vesicle recycling. The enzyme gene FOR inhibits synaptic vesicle exocytosis during low-frequency stimulation by negatively regulating presynaptic Ca2+ levels and maintains neurotransmission during high-frequency stimulation by facilitating synaptic vesicle endocytosis. Additionally, glial FOR gene negatively regulated nerve terminal growth through TGF-beta signalling, and this developmental effect is independent of the effects of the enzyme gene on neurotransmission. Overall, the enzyme gene plays a critical role in coupling synaptic vesicle exocytosis and endocytosis, thereby balancing these two components to maintain sustained neurotransmission | Drosophila melanogaster |
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