Activating Compound | Comment | Organism | Structure |
---|---|---|---|
8-bromo-cGMP | - |
Homo sapiens | |
8-bromo-cGMP | - |
Rattus norvegicus | |
cGMP | - |
Homo sapiens | |
cGMP | - |
Rattus norvegicus | |
additional information | mechanical stress also induces the enzyme, e.g. in lung epithelial cells, umbilical vein endothelial cells, and osteoblasts | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | PKG1, primarily in cGMP untreated cells | Homo sapiens | 5737 | - |
cytoplasm | PKG1, primarily in cGMP untreated cells | Rattus norvegicus | 5737 | - |
nucleus | PKG1, primarily in cGMP or 8-bromo-cGMp treated cells | Homo sapiens | 5634 | - |
nucleus | PKG1, primarily in cGMP or 8-bromo-cGMp treated cells | Rattus norvegicus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | transcriptional regulation by the cgMP/PKG pathway affects the amount of IL-6 expression, cGMP-induced PKG activates the IL-6 promoter involving cis-acting DNA elements and transcription factors, the activation is prevented by actinomycin D, regulation system, overview | ? | - |
? | |
additional information | Rattus norvegicus | transcriptional regulation by the cgMP/PKG pathway affects the amount of IL-6 expression, cGMP-induced PKG activates the IL-6 promoter involving cis-acting DNA elements and transcription factors, the activation is prevented by actinomycin D, regulation system, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | - |
Homo sapiens | - |
lung | epithelium | Homo sapiens | - |
osteoblast | primary | Homo sapiens | - |
osteosarcoma cell | - |
Rattus norvegicus | - |
umbilical vein endothelium | - |
Homo sapiens | - |
UMR-106 cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | transcriptional regulation by the cgMP/PKG pathway affects the amount of IL-6 expression, cGMP-induced PKG activates the IL-6 promoter involving cis-acting DNA elements and transcription factors, the activation is prevented by actinomycin D, regulation system, overview | Homo sapiens | ? | - |
? | |
additional information | transcriptional regulation by the cgMP/PKG pathway affects the amount of IL-6 expression, cGMP-induced PKG activates the IL-6 promoter involving cis-acting DNA elements and transcription factors, the activation is prevented by actinomycin D, regulation system, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
guanosine 3,5-cyclic monophosphate-dependent protein kinase | - |
Homo sapiens |
guanosine 3,5-cyclic monophosphate-dependent protein kinase | - |
Rattus norvegicus |
PKG | - |
Homo sapiens |
PKG | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus |