Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cGMP | - |
Homo sapiens | |
lipopolysaccharides | induces enzyme expression and activates the enzyme | Homo sapiens | |
NO | - |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is regulated via negative feedback | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + vasodilator stimulated phosphoprotein | Homo sapiens | phosphorylation of vasodilator stimulated phosphoprotein, i.e. VASP, induces detachment of VASP and other cytoskeletal proteins from focal adhesion, phosphorylated VASP may prevent dendritic cells from migrating towards CCl19 | ADP + phosphorylated vasodilator stimulated phosphoprotein | - |
? | |
additional information | Homo sapiens | NO and cGMP protein kinase regulate dendritic-cell migration toward the lymph-node-directing chemokine CCL19, cGMP/cGK pathway, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dendritic cell | derived from CD14+ monocytes | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + vasodilator stimulated phosphoprotein | phosphorylation of vasodilator stimulated phosphoprotein, i.e. VASP, induces detachment of VASP and other cytoskeletal proteins from focal adhesion, phosphorylated VASP may prevent dendritic cells from migrating towards CCl19 | Homo sapiens | ADP + phosphorylated vasodilator stimulated phosphoprotein | - |
? | |
ATP + vasodilator stimulated phosphoprotein | phosphorylation at Ser239 | Homo sapiens | ADP + phosphorylated vasodilator stimulated phosphoprotein | - |
? | |
additional information | NO and cGMP protein kinase regulate dendritic-cell migration toward the lymph-node-directing chemokine CCL19, cGMP/cGK pathway, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CGK | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |