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Literature summary for 2.7.11.12 extracted from

  • Roberts, J.D.; Chiche, J.D.; Kolpa, E.M.; Bloch, D.B.; Bloch, K.D.
    cGMP-dependent protein kinase I interacts with TRIM39R, a novel Rpp21 domain-containing TRIM protein (2007), Am. J. Physiol. Lung Cell Mol. Physiol., 293, L903-L912.
    View publication on PubMed
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
cGMP
-
 Homo sapiens
NO NO stimulates PKGI in vascular smooth umscle cells contributing to cytoskelatl kinetics and phenotype, overview Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
alternate splicing of the 5' end of a pre-mRNA encoded by a single gene results in isozymes alpha and beta PKGI, expression of the constitutively active catalytic region of PKGI from a lung cDNA library, and co-expression with TRIM39R in a yeast two hybrid system Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + TRIM39 Homo sapiens
-
 ADP + phosphorylated TRIM39
-
 ?
ATP + TRIM39R Homo sapiens PKGI interacts with TRIM39R, a Rpp21 domain-containing TRIM protein, in the kinase phosphorylation domain ADP + phosphorylated TRIM39R
-
 ?
additional information Homo sapiens PKGI, in part, mediates the regulation of pulmonary cell proliferation and phenotype caused by NO and cGMP, in cells that lack PKGI such as highly passaged vascular smooth muscle cells, NO and cGMP do not regulate cell proliferation and phenotype ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 two isozymes alpha and beta of PKGI
-

Source Tissue

Source Tissue Comment Organism Textmining
HEp-2 cell
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
smooth muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + TRIM39
-
 Homo sapiens ADP + phosphorylated TRIM39
-
 ?
ATP + TRIM39 phosphorylation of the tripartite motif protein 39 in the conserved phosphorylation domain by PKGI, recombinantly expresses TRIM39 substrate Homo sapiens ADP + phosphorylated TRIM39
-
 ?
ATP + TRIM39R PKGI interacts with TRIM39R, a Rpp21 domain-containing TRIM protein, in the kinase phosphorylation domain Homo sapiens ADP + phosphorylated TRIM39R
-
 ?
ATP + TRIM39R phosphorylation of the endogenous putative PKGI-interactor and TRIM39 variant in the conserved phosphorylation domain by PKGI, recombinantly expresses TRIM39R substrate Homo sapiens ADP + phosphorylated TRIM39R
-
 ?
additional information PKGI, in part, mediates the regulation of pulmonary cell proliferation and phenotype caused by NO and cGMP, in cells that lack PKGI such as highly passaged vascular smooth muscle cells, NO and cGMP do not regulate cell proliferation and phenotype Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
cGMP-dependent protein kinase I
-
 Homo sapiens
PKGI
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens