Activating Compound | Comment | Organism | Structure |
---|---|---|---|
8-pCPT-CGMP | i.e. i.e. 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate, cGMP analogue, membrane-permeable | Homo sapiens | |
cGMP | dependent on | Homo sapiens | |
additional information | cGKI activity is induced by NO via increased cGMP production | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Rp-8-pCPT-cGMP | i.e. Rp-8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate, cGKI inhibitor, reverses the NO effects | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the NO/cGMP pathway including inhibits Ca2+-dependent and turbulence-induced Rap 1 activation in human platelets mediated by cGKI in platelets and megakaryocytes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Homo sapiens | - |
MEG-01 cell | megakaryocyte cell line | Homo sapiens | - |
megakaryocyte | MEG-01 cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + VASP | - |
Homo sapiens | ADP + VAS(P)P | - |
? | |
additional information | the NO/cGMP pathway including inhibits Ca2+-dependent and turbulence-induced Rap 1 activation in human platelets mediated by cGKI in platelets and megakaryocytes | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cGKI | - |
Homo sapiens |
cGMP-dependent protein kinase I | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |