Activating Compound | Comment | Organism | Structure |
---|---|---|---|
20 kDa heat shock protein | i.e. Hsp20, involved in cGKI-induced smooth muscle relaxation, probably via the actin binding sequence | Mammalia | |
cGMP | - |
Mammalia | |
additional information | NO induces cGMP production which activates the enzyme | Mammalia |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mammalia | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + IRAG | Mammalia | i.e. inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate, phosphorylation by isoyzme cGKIbeta, which is complexed with the substrate and the inositol 1,4,5-trisphosphate receptor in a ternary complex | ADP + phosphorylated IRAG | - |
? | |
ATP + maxiK channel | Mammalia | phosphorylation by isoyzme cGKI enhances the channel activity | ADP + phosphorylated maxiK channel | - |
? | |
ATP + myosin phosphatase | Mammalia | phosphorylation by isoyzme cGKIalpha leads to decreased level of phosphorylated MLC | ADP + phosphorylated RhoA | - |
? | |
ATP + phosphodiesterase 5 | Mammalia | phosphorylation at Ser92 by isoyzme cGKI leads to enhanced hydrolysis of cGMP, regulatory function | ADP + phosphorylated phosphodiesterase 5 | - |
? | |
ATP + RhoA | Mammalia | phosphorylation at Ser188 by isoyzme cGKI leading to translocation of RhoA from the membrane to the cytosol and inactivates RhoA | ADP + phosphorylated RhoA | - |
? | |
ATP + troponin T | Mammalia | phosphorylation by isoyzme cGKI in cardiomyocytes | ADP + phosphorylated troponin T | - |
? | |
additional information | Mammalia | the enzyme activates diverse signal transduction pathways, isozyme cGKI is responsible for smooth muscle relaxation by lowering the cytosolic calcium level and/or by desensitization of the contractile elements, smooth muscle contraction and enzyme-mediated smooth muscle relaxation mechanisms, detailed overview, cGKI affects the Ca2+ efflux from the endoplasmic reticulum and the cytosolic Ca2+ concentration | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalia | - |
isozymes cGKI and cGKII | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiomyocyte | - |
Mammalia | - |
smooth muscle | e.g. aortic | Mammalia | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + IRAG | i.e. inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate, phosphorylation by isoyzme cGKIbeta, which is complexed with the substrate and the inositol 1,4,5-trisphosphate receptor in a ternary complex | Mammalia | ADP + phosphorylated IRAG | - |
? | |
ATP + IRAG | i.e. inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate, phosphorylation by isoyzme cGKIbeta | Mammalia | ADP + phosphorylated IRAG | - |
? | |
ATP + maxiK channel | phosphorylation by isoyzme cGKI enhances the channel activity | Mammalia | ADP + phosphorylated maxiK channel | - |
? | |
ATP + maxiK channel | phosphorylation of the PKC-phosphorylated substrate at Ser1072 by isoyzme cGKI | Mammalia | ADP + phosphorylated maxiK channel | - |
? | |
ATP + myosin phosphatase | phosphorylation by isoyzme cGKIalpha leads to decreased level of phosphorylated MLC | Mammalia | ADP + phosphorylated RhoA | - |
? | |
ATP + myosin phosphatase | i.e. MP, phosphorylation of the 130 kDa myosin-binding subunit by isoyzme cGKIalpha | Mammalia | ADP + phosphorylated RhoA | - |
? | |
ATP + phosphodiesterase 5 | phosphorylation at Ser92 by isoyzme cGKI leads to enhanced hydrolysis of cGMP, regulatory function | Mammalia | ADP + phosphorylated phosphodiesterase 5 | - |
? | |
ATP + phosphodiesterase 5 | phosphorylation at Ser92 by isoyzme cGKI | Mammalia | ADP + phosphorylated phosphodiesterase 5 | - |
? | |
ATP + RhoA | phosphorylation at Ser188 by isoyzme cGKI leading to translocation of RhoA from the membrane to the cytosol and inactivates RhoA | Mammalia | ADP + phosphorylated RhoA | - |
? | |
ATP + RhoA | phosphorylation at Ser188 by isoyzme cGKI | Mammalia | ADP + phosphorylated RhoA | - |
? | |
ATP + troponin T | phosphorylation by isoyzme cGKI in cardiomyocytes | Mammalia | ADP + phosphorylated troponin T | - |
? | |
ATP + troponin T | phosphorylation by isoyzme cGKI | Mammalia | ADP + phosphorylated troponin T | - |
? | |
additional information | the enzyme activates diverse signal transduction pathways, isozyme cGKI is responsible for smooth muscle relaxation by lowering the cytosolic calcium level and/or by desensitization of the contractile elements, smooth muscle contraction and enzyme-mediated smooth muscle relaxation mechanisms, detailed overview, cGKI affects the Ca2+ efflux from the endoplasmic reticulum and the cytosolic Ca2+ concentration | Mammalia | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CGK | - |
Mammalia |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mammalia |