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Literature summary for 2.7.11.11 extracted from

  • Takahashi, M.; Li, Y.; Dillon, T.J.; Stork, P.J.
    Phosphorylation of Rap1 by cAMP-dependent protein kinase (PKA) creates a binding site for KSR to sustain ERK activation by cAMP (2017), J. Biol. Chem., 292, 1449-1461 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Rap1a Homo sapiens phosphorylation of Rap1a on serine 180. Phosphorylation creates potential binding sites for the adaptor protein 14-3-3 that links Rap1 to the scaffold protein KSR. Because KSR can exist as a dimer with B-Raf, this provides Rap1 an indirect link to B-Raf and the MAP kinase cascade ADP + phosphorylated Rap1a
-
 ?
ATP + Rap1b Homo sapiens phosphorylation of Rap1b on serine 179. Phosphorylation creates potential binding sites for the adaptor protein 14-3-3 that links Rap1 to the scaffold protein KSR ADP + phosphorylated Rap1b
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P05132
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-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Rap1a phosphorylation of Rap1a on serine 180. Phosphorylation creates potential binding sites for the adaptor protein 14-3-3 that links Rap1 to the scaffold protein KSR. Because KSR can exist as a dimer with B-Raf, this provides Rap1 an indirect link to B-Raf and the MAP kinase cascade Homo sapiens ADP + phosphorylated Rap1a
-
 ?
ATP + Rap1a phosphorylation of Rap1a on serine 180 Homo sapiens ADP + phosphorylated Rap1a
-
 ?
ATP + Rap1b phosphorylation of Rap1b on serine 179. Phosphorylation creates potential binding sites for the adaptor protein 14-3-3 that links Rap1 to the scaffold protein KSR Homo sapiens ADP + phosphorylated Rap1b
-
 ?
ATP + Rap1b phosphorylation of Rap1b on serine 179 Homo sapiens ADP + phosphorylated Rap1b
-
 ?

Synonyms

Synonyms Comment Organism
PKA
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 Homo sapiens