Activating Compound | Comment | Organism | Structure |
---|---|---|---|
D-glucose | increases phosphorylation of beta-catenin on Ser552 in INS-1E beta-cells | Rattus norvegicus | |
N6,2'-O-dibutyryl-cAMP | increases phosphorylation of beta-catenin on Ser552 in INS-1E beta-cells | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-catenin | Rattus norvegicus | - |
ADP + phosphorylated beta-cateniin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
INS-1E cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-catenin | - |
Rattus norvegicus | ADP + phosphorylated beta-cateniin | - |
? | |
ATP + beta-catenin | phosphorylation on Ser552 and Ser675 | Rattus norvegicus | ADP + phosphorylated beta-cateniin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cAMP/protein kinase A | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | PKA catalyzed phosphorylation of beta-catenin at Ser552 and Ser675 results in stabilization of the protein and activation of its transcriptional activity. beta-Catenin is required for the glucose-dependent increase in cyclin D1 expression in INS-1E beta-cells | Rattus norvegicus |