Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | gamma-hydroxybutyrate induces the enzyme in the hippocampus, the phosphorylation activity is increased via GABAB receptors, but a desensitization of the signaling pathway occurs after repeated administration of gamma-hydroxybutyrate, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
H-89 | i.e. N-[2-((4-bromocinnamyl)amino)ethyl]5-isoquinolinesulfonamide, as hydrochloride | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + cAMP-responsive element binding protein | Mus musculus | the enzyme as well as GABAB receptors are involved in induction of cAMP-responsive element binding protein phosphorylation in hippocampus by gamma-hydroxybutyrate, overview | ADP + phosphorylated cAMP-responsive element binding protein | - |
? | |
ATP + cAMP-responsive element binding protein | Mus musculus C57BL/6 | the enzyme as well as GABAB receptors are involved in induction of cAMP-responsive element binding protein phosphorylation in hippocampus by gamma-hydroxybutyrate, overview | ADP + phosphorylated cAMP-responsive element binding protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57/BL6 mice | - |
Mus musculus C57BL/6 | - |
C57/BL6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
hippocampus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + cAMP-responsive element binding protein | i.e. CREB | Mus musculus | ADP + phosphorylated cAMP-responsive element binding protein | - |
? | |
ATP + cAMP-responsive element binding protein | the enzyme as well as GABAB receptors are involved in induction of cAMP-responsive element binding protein phosphorylation in hippocampus by gamma-hydroxybutyrate, overview | Mus musculus | ADP + phosphorylated cAMP-responsive element binding protein | - |
? | |
ATP + cAMP-responsive element binding protein | i.e. CREB | Mus musculus C57BL/6 | ADP + phosphorylated cAMP-responsive element binding protein | - |
? | |
ATP + cAMP-responsive element binding protein | the enzyme as well as GABAB receptors are involved in induction of cAMP-responsive element binding protein phosphorylation in hippocampus by gamma-hydroxybutyrate, overview | Mus musculus C57BL/6 | ADP + phosphorylated cAMP-responsive element binding protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKA | - |
Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |