Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3R,4R,5R)-3,4-dihydroxy-5-(3-methoxybenzyloxy)cyclohex-1-ene-1-carboxylic acid | - |
Helicobacter pylori | |
(3R,4R,5R)-3,4-dihydroxy-5-(3-methoxybenzyloxy)cyclohex-1-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
(3R,4R,5R)-3,4-dihydroxy-5-(3-methylbenzyloxy)cyclohex-1-ene-1-carboxylic acid | - |
Helicobacter pylori | |
(3R,4R,5R)-3,4-dihydroxy-5-(3-methylbenzyloxy)cyclohex-1-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
(3R,4R,5R)-3,4-dihydroxy-5-(4-methylbenzyloxy)cyclohex-1-ene-1-carboxylic acid | - |
Helicobacter pylori | |
(3R,4R,5R)-3,4-dihydroxy-5-(4-methylbenzyloxy)cyclohex-1-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
(3R,4R,5R)-3,4-dihydroxy-5-(naphthyl-2-yl)methoxycyclohex-1-ene-1-carboxylic acid | - |
Helicobacter pylori | |
(3R,4R,5R)-3,4-dihydroxy-5-(naphthyl-2-yl)methoxycyclohex-1-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
(3R,4R,5R)-5-(3-fluorobenzyloxy)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | - |
Helicobacter pylori | |
(3R,4R,5R)-5-(3-fluorobenzyloxy)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
(3R,4R,5R)-5-(benzo[b]thiophen-5-yl)methoxy-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | - |
Helicobacter pylori | |
(3R,4R,5R)-5-(benzo[b]thiophen-5-yl)methoxy-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
(3R,4R,5R)-5-benzyloxy-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | - |
Helicobacter pylori | |
(3R,4R,5R)-5-benzyloxy-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
(3R,4S,5R)-5-(4-benzyl-1H-1,2,3-triazol-1-yl)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | - |
Helicobacter pylori | |
(3R,4S,5R)-5-(4-benzyl-1H-1,2,3-triazol-1-yl)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
(3R,4S,5R)-5-(4-phenoxymethyl-1H-1,2,3-triazol-1-yl)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | - |
Helicobacter pylori | |
(3R,4S,5R)-5-(4-phenoxymethyl-1H-1,2,3-triazol-1-yl)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
(3S)-3-aminoshikimic acid | competitive reversible inhibitor | Helicobacter pylori | |
(3S)-3-aminoshikimic acid | competitive reversible inhibitor | Mycobacterium tuberculosis | |
sodium (3R,4R,5R)-3,4-dihydroxy-5-((perfluorophenyl)methoxy)-cyclohex-1-ene-1-carboxylate | - |
Helicobacter pylori | |
sodium (3R,4R,5R)-3,4-dihydroxy-5-((perfluorophenyl)methoxy)-cyclohex-1-ene-1-carboxylate | - |
Mycobacterium tuberculosis | |
sodium (3R,4R,5R)-3,4-dihydroxy-5-(3-nitrobenzyloxy)cyclohex-1-ene-1-carboxylate | - |
Helicobacter pylori | |
sodium (3R,4R,5R)-3,4-dihydroxy-5-(3-nitrobenzyloxy)cyclohex-1-ene-1-carboxylate | - |
Mycobacterium tuberculosis | |
sodium (3S,4R,5R)-3-amino-5-(benzo[b]thiophen-5-yl)-methoxy-4-hydroxycyclohex-1-ene-carboxylate | - |
Helicobacter pylori | |
sodium (3S,4R,5R)-3-amino-5-(benzo[b]thiophen-5-yl)-methoxy-4-hydroxycyclohex-1-ene-carboxylate | - |
Mycobacterium tuberculosis | |
sodium (3S,4S,5R)-3-amino-4-hydroxy-5-(naphth-2-yl)-metoxycyclohex-1-ene-carboxylate | - |
Helicobacter pylori | |
sodium (3S,4S,5R)-3-amino-4-hydroxy-5-(naphth-2-yl)-metoxycyclohex-1-ene-carboxylate | - |
Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + shikimate | Mycobacterium tuberculosis | - |
ADP + 3-phosphoshikimate | - |
? | |
ATP + shikimate | Helicobacter pylori | - |
ADP + 3-phosphoshikimate | - |
? | |
ATP + shikimate | Mycobacterium tuberculosis H37Rv | - |
ADP + 3-phosphoshikimate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Helicobacter pylori | P56073 | - |
- |
Mycobacterium tuberculosis | P9WPY3 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WPY3 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + shikimate | - |
Mycobacterium tuberculosis | ADP + 3-phosphoshikimate | - |
? | |
ATP + shikimate | - |
Helicobacter pylori | ADP + 3-phosphoshikimate | - |
? | |
ATP + shikimate | - |
Mycobacterium tuberculosis H37Rv | ADP + 3-phosphoshikimate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AroK | - |
Helicobacter pylori |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00046 | - |
sodium (3R,4R,5R)-3,4-dihydroxy-5-(3-nitrobenzyloxy)cyclohex-1-ene-1-carboxylate | at pH 7.7 and 25°C | Helicobacter pylori | |
0.00056 | - |
(3R,4R,5R)-5-(benzo[b]thiophen-5-yl)methoxy-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | at pH 7.7 and 25°C | Helicobacter pylori | |
0.001 | - |
(3R,4R,5R)-3,4-dihydroxy-5-(3-methoxybenzyloxy)cyclohex-1-ene-1-carboxylic acid | at pH 7.7 and 25°C | Helicobacter pylori | |
0.00128 | - |
(3R,4R,5R)-5-(3-fluorobenzyloxy)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | at pH 7.7 and 25°C | Helicobacter pylori | |
0.0018 | - |
(3R,4R,5R)-3,4-dihydroxy-5-(naphthyl-2-yl)methoxycyclohex-1-ene-1-carboxylic acid | at pH 7.7 and 25°C | Helicobacter pylori | |
0.0021 | - |
(3R,4R,5R)-3,4-dihydroxy-5-(3-methylbenzyloxy)cyclohex-1-ene-1-carboxylic acid | at pH 7.7 and 25°C | Helicobacter pylori | |
0.003 | - |
(3R,4R,5R)-5-benzyloxy-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | at pH 7.7 and 25°C | Helicobacter pylori | |
0.01 | - |
sodium (3R,4R,5R)-3,4-dihydroxy-5-(3-nitrobenzyloxy)cyclohex-1-ene-1-carboxylate | at pH 7.7 and 25°C | Mycobacterium tuberculosis | |
0.0109 | - |
(3R,4R,5R)-3,4-dihydroxy-5-(4-methylbenzyloxy)cyclohex-1-ene-1-carboxylic acid | at pH 7.7 and 25°C | Helicobacter pylori | |
0.022 | - |
(3R,4R,5R)-3,4-dihydroxy-5-(naphthyl-2-yl)methoxycyclohex-1-ene-1-carboxylic acid | at pH 7.7 and 25°C | Mycobacterium tuberculosis | |
0.036 | - |
(3R,4R,5R)-5-benzyloxy-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | at pH 7.7 and 25°C | Mycobacterium tuberculosis | |
0.041 | - |
sodium (3R,4R,5R)-3,4-dihydroxy-5-((perfluorophenyl)methoxy)-cyclohex-1-ene-1-carboxylate | at pH 7.7 and 25°C | Helicobacter pylori | |
0.043 | - |
(3R,4R,5R)-5-(benzo[b]thiophen-5-yl)methoxy-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | at pH 7.7 and 25°C | Mycobacterium tuberculosis | |
0.067 | - |
(3R,4S,5R)-5-(4-phenoxymethyl-1H-1,2,3-triazol-1-yl)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | at pH 7.7 and 25°C | Helicobacter pylori | |
0.095 | - |
(3R,4S,5R)-5-(4-benzyl-1H-1,2,3-triazol-1-yl)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | at pH 7.7 and 25°C | Helicobacter pylori | |
0.109 | - |
(3R,4R,5R)-3,4-dihydroxy-5-(3-methylbenzyloxy)cyclohex-1-ene-1-carboxylic acid | at pH 7.7 and 25°C | Mycobacterium tuberculosis | |
0.135 | - |
(3R,4R,5R)-3,4-dihydroxy-5-(3-methoxybenzyloxy)cyclohex-1-ene-1-carboxylic acid | at pH 7.7 and 25°C | Mycobacterium tuberculosis | |
0.166 | - |
(3R,4R,5R)-3,4-dihydroxy-5-(4-methylbenzyloxy)cyclohex-1-ene-1-carboxylic acid | at pH 7.7 and 25°C | Mycobacterium tuberculosis | |
0.18 | - |
(3R,4R,5R)-5-(3-fluorobenzyloxy)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | at pH 7.7 and 25°C | Mycobacterium tuberculosis | |
0.415 | - |
sodium (3S,4R,5R)-3-amino-5-(benzo[b]thiophen-5-yl)-methoxy-4-hydroxycyclohex-1-ene-carboxylate | at pH 7.7 and 25°C | Mycobacterium tuberculosis | |
0.535 | - |
sodium (3S,4R,5R)-3-amino-5-(benzo[b]thiophen-5-yl)-methoxy-4-hydroxycyclohex-1-ene-carboxylate | at pH 7.7 and 25°C | Helicobacter pylori | |
0.71 | - |
sodium (3R,4R,5R)-3,4-dihydroxy-5-((perfluorophenyl)methoxy)-cyclohex-1-ene-1-carboxylate | at pH 7.7 and 25°C | Mycobacterium tuberculosis | |
0.8 | - |
sodium (3S,4S,5R)-3-amino-4-hydroxy-5-(naphth-2-yl)-metoxycyclohex-1-ene-carboxylate | Ki above 0.8 mM, at pH 7.7 and 25°C | Helicobacter pylori | |
2 | - |
(3R,4S,5R)-5-(4-benzyl-1H-1,2,3-triazol-1-yl)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | Ki above 2.0 mM, at pH 7.7 and 25°C | Mycobacterium tuberculosis | |
2 | - |
(3R,4S,5R)-5-(4-phenoxymethyl-1H-1,2,3-triazol-1-yl)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid | Ki above 2.0 mM, at pH 7.7 and 25°C | Mycobacterium tuberculosis | |
2 | - |
sodium (3S,4S,5R)-3-amino-4-hydroxy-5-(naphth-2-yl)-metoxycyclohex-1-ene-carboxylate | Ki above 2.0 mM, at pH 7.7 and 25°C | Mycobacterium tuberculosis |