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Information on EC 2.7.1.71 - shikimate kinase
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2.7.1.71 shikimate kinaseSpecify your search results
Word Map
- 2.7.1.71
- chorismate
-
shikimate-3-phosphate
- chrysanthemi
- oseltamivir
- dahp
-
5-enolpyruvylshikimate
-
3-deoxy-d-arabino-heptulosonate
- dehydroquinate
- 7-phosphate
- drug development
- synthesis
The enzyme appears in viruses and cellular organisms
Synonyms
shikimate kinase, shikimate kinase ii, atsk1, atsk2, ossk1, ossk2, ossk3, atp:shikimate 3-phosphotransferase, sk ii, shikimate kinase-like 1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AroK
AroL
kinase (phosphorylating), shikimate
-
-
-
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kinase, shikimate (phosphorylating)
-
-
-
-
MtSK
Rv2539c
shikimate kinase II
-
-
-
-
SK I
SK2
SKI
-
-
-
-
SKII
-
-
-
-
type I shikimate kinase, aroK-encoded
AroK
-
-
-
-
AroL
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + shikimate = ADP + 3-phosphoshikimate
the enzyme binds substrates randomly and in a synergistic fashion
-
ATP + shikimate = ADP + 3-phosphoshikimate
phosphoryl transfer mechanism of shikimate kinase, overview
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ATP + shikimate = ADP + 3-phosphoshikimate
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
ATP:shikimate 3-phosphotransferase
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CAS REGISTRY NUMBER
COMMENTARY
9031-51-0
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + shikimate
ADP + 3-phosphoshikimate
-
-
-
-
?
ATP + shikimate
ADP + 3-phosphoshikimate
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specific phosphorylation of the 3-hydroxy group of shikimate
-
-
?
ATP + shikimate
ADP + 3-phosphoshikimate
-
-
-
?
ATP + shikimate
ADP + shikimate 3-phosphate
-
-
-
-
?
ATP + shikimate
ADP + shikimate 3-phosphate
-
SK2 is the isoenzyme that normally functions in aromatic biosynthesis in the cell, SK1 functions only when high intracellular levels of shikimate occurs
-
?
ATP + shikimate
ADP + shikimate 3-phosphate
fifth step in the shikimate pathway
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-
?
ATP + shikimate
ADP + shikimate 3-phosphate
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the enzyme catalyzes the committed step in the seven-step biosynthesis of chorismate
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-
?
ATP + shikimate
ADP + shikimate 3-phosphate
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the substrate binds in a pocket lined with hydrophobic residues and interacts with several highly conserved charged residues including Asp34, Arg58,Glu61 and Arg136 which project into the cavity
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-
?
ATP + shikimate
ADP + shikimate 3-phosphate
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-
-
?
ATP + shikimate
ADP + shikimate 3-phosphate
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-
-
-
?
ATP + shikimate
ADP + shikimate 3-phosphate
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energy charge plays a role in regulating shikimate kinase, thereby controlling the shikimate pathway
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-
?
additional information
?
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AtSK2 shikimate binding residues include Gly177, Gly178, Gly179, and Asp130 of the Walker B motif and Phe146, Phe154, Glu158, Arg155, and Arg243
-
-
?
additional information
?
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AtSK2 shikimate binding residues include Gly177, Gly178, Gly179, and Asp130 of the Walker B motif and Phe146, Phe154, Glu158, Arg155, and Arg243
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-
?
additional information
?
-
differential expression of the three rice SK genes OsSK1, OsSK2, and OsSK3, and the accompanying changes in the production of shikimate 3-phosphate may contribute to the defense response and to panicle development in rice
-
-
?
additional information
?
-
differential expression of the three rice SK genes OsSK1, OsSK2, and OsSK3, and the accompanying changes in the production of shikimate 3-phosphate may contribute to the defense response and to panicle development in rice
-
-
?
additional information
?
-
differential expression of the three rice SK genes OsSK1, OsSK2, and OsSK3, and the accompanying changes in the production of shikimate 3-phosphate may contribute to the defense response and to panicle development in rice
-
-
?
additional information
?
-
-
differential expression of the three rice SK genes OsSK1, OsSK2, and OsSK3, and the accompanying changes in the production of shikimate 3-phosphate may contribute to the defense response and to panicle development in rice
-
-
?
additional information
?
-
differential expression of the three rice SK genes OsSK1,OsSK2, and OsSK3, and the accompanying changes in the production of shikimate 3-phosphate may contribute to the defense response and to panicle development in rice
-
-
?
additional information
?
-
differential expression of the three rice SK genes OsSK1,OsSK2, and OsSK3, and the accompanying changes in the production of shikimate 3-phosphate may contribute to the defense response and to panicle development in rice
-
-
?
additional information
?
-
differential expression of the three rice SK genes OsSK1,OsSK2, and OsSK3, and the accompanying changes in the production of shikimate 3-phosphate may contribute to the defense response and to panicle development in rice
-
-
?
additional information
?
-
-
differential expression of the three rice SK genes OsSK1,OsSK2, and OsSK3, and the accompanying changes in the production of shikimate 3-phosphate may contribute to the defense response and to panicle development in rice
-
-
?
additional information
?
-
-
no activity with XTP, ITP, GTP, TTP, CTP and UTP
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + shikimate
ADP + 3-phosphoshikimate
-
-
-
-
?
ATP + shikimate
ADP + 3-phosphoshikimate
-
-
-
?
ATP + shikimate
ADP + shikimate 3-phosphate
-
SK2 is the isoenzyme that normally functions in aromatic biosynthesis in the cell, SK1 functions only when high intracellular levels of shikimate occurs
-
?
ATP + shikimate
ADP + shikimate 3-phosphate
fifth step in the shikimate pathway
-
-
?
ATP + shikimate
ADP + shikimate 3-phosphate
-
the enzyme catalyzes the committed step in the seven-step biosynthesis of chorismate
-
-
?
ATP + shikimate
ADP + shikimate 3-phosphate
-
energy charge plays a role in regulating shikimate kinase, thereby controlling the shikimate pathway
-
-
?
additional information
?
-
differential expression of the three rice SK genes OsSK1, OsSK2, and OsSK3, and the accompanying changes in the production of shikimate 3-phosphate may contribute to the defense response and to panicle development in rice
-
-
?
additional information
?
-
differential expression of the three rice SK genes OsSK1, OsSK2, and OsSK3, and the accompanying changes in the production of shikimate 3-phosphate may contribute to the defense response and to panicle development in rice
-
-
?
additional information
?
-
differential expression of the three rice SK genes OsSK1, OsSK2, and OsSK3, and the accompanying changes in the production of shikimate 3-phosphate may contribute to the defense response and to panicle development in rice
-
-
?
additional information
?
-
-
differential expression of the three rice SK genes OsSK1, OsSK2, and OsSK3, and the accompanying changes in the production of shikimate 3-phosphate may contribute to the defense response and to panicle development in rice
-
-
?
additional information
?
-
differential expression of the three rice SK genes OsSK1,OsSK2, and OsSK3, and the accompanying changes in the production of shikimate 3-phosphate may contribute to the defense response and to panicle development in rice
-
-
?
additional information
?
-
differential expression of the three rice SK genes OsSK1,OsSK2, and OsSK3, and the accompanying changes in the production of shikimate 3-phosphate may contribute to the defense response and to panicle development in rice
-
-
?
additional information
?
-
differential expression of the three rice SK genes OsSK1,OsSK2, and OsSK3, and the accompanying changes in the production of shikimate 3-phosphate may contribute to the defense response and to panicle development in rice
-
-
?
additional information
?
-
-
differential expression of the three rice SK genes OsSK1,OsSK2, and OsSK3, and the accompanying changes in the production of shikimate 3-phosphate may contribute to the defense response and to panicle development in rice
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ATP
-
the adenyl moiety of ATP plays a direct role in the regulation of ATP binding and/or phosphoryl transfer, role of the C8 proton of ATP and conserved Thr residues interacting with the C8-H in the catalysis of shikimate kinase, mechanism, overview
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Cd2+
-
requirement for Mg2+ can partially be replaced by Mn2+, Ca2+, Co2+ and Cd2+
Cl-
increases the stability of the structure of the enzyme and influences the affinity of ADP for shikimate kinase
Co2+
Fe2+
Mg2+
Mn2+
Ni2+
-
divalent cation required, Mg2+ and Mn2+ are most effective, Ca2+ activates to a lesser extent
Ca2+
-
divalent cations required, Mg2+ is most effective, but significant activity is obtained with Fe2+, Ca2+, Mn2+ or Co2+, isoenzyme SK2
Ca2+
-
divalent cation required, Mg2+ and Mn2+ are most effective, Ca2+ activates to a lesser extent
Ca2+
-
requirement for Mg2+ can partially be replaced by Mn2+, Ca2+, Co2+ and Cd2+
Co2+
-
divalent cations required, Mg2+ is most effective, but significant activity is obtained with Fe2+, Ca2+, Mn2+ or Co2+, isoenzyme SK2
Co2+
-
divalent cation required, Mg2+ and Mn2+ are most effective, Co2+ activates to a lesser extent
Co2+
-
requirement for Mg2+ can partially be replaced by Mn2+, Ca2+, Co2+ and Cd2+
Fe2+
-
divalent cations required, Mg2+ is most effective, but significant activity is obtained with Fe2+, Ca2+, Mn2+ or Co2+, isoenzyme SK2
Fe2+
-
divalent cation required, Mg2+ and Mn2+ are most effective, Fe2+ activates to a lesser extent
Mg2+
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in the enzyme that contains bound MgADP- the binding of Mg2+ in the active site involves direct interaction with two protein side-chains
Mg2+
-
divalent cations required, Mg2+ is most effective, but significant activity is obtained with Fe2+, Ca2+, Mn2+ or Co2+, isoenzyme SK2
Mg2+
influences the position of the hydroxyl groups of the shikimate molecule and some of the residues of the active site of the enzyme
Mg2+
-
divalent cation required, Mg2+ and Mn2+ are most effective. Optimal Mg2+ concentration is 10 mM
Mg2+
-
divalent cation required, Mg2+ is most effective followed by Mn2+. Optimal Mg2+ concentration is 2.4 mM
Mg2+
-
requirement for Mg2+ can partially be replaced by Mn2+, Ca2+, Co2+ and Cd2+
Mn2+
-
divalent cations required, Mg2+ is most effective, but significant activity is obtained with Fe2+, Ca2+, Mn2+ or Co2+, isoenzyme SK2
Mn2+
-
requirement for Mg2+ can partially be replaced by Mn2+, Ca2+, Co2+ and Cd2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(1R,6S,10S)-4-benzyloxymethyl-6,10-dihydroxy-2-oxabicyclo[4.3.1]deca-4(Z),7-diene-8-carboxylic acid
(1R,6S,10S)-4-cyclopropylmethyl-6,10-dihydroxy-2-oxabicyclo[4.3.1]deca-4(Z),7-diene-8-carboxylic acid
(1R,6S,10S)-4-ethoxymethyl-6,10-dihydroxy-2-oxabicyclo[4.3.1]deca-4(Z),7-diene-8-carboxylic acid
(1R,6S,10S)-4-hydroxylmethyl-6,10-dihydroxy-2-oxabicyclo[4.3.1]deca-4(Z),7-diene-8-carboxylic acid
(1R,6S,10S)-6,10-dihydroxy-4-methyl-2-oxabicyclo[4.3.1]deca-4(Z),7-diene-8-carboxylic acid
(1R,6S,10S)-6,10-dihydroxy-4-propyl-2-oxabicyclo[4.3.1]deca-4(Z),7-diene-8-carboxylic acid
(2E)-3-(4-hydroxy-3-methoxyphenyl)-2-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]prop-2-enenitrile
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uncompetitive inhibition towards shikimate and competitive inhibition towards ATP
(2E)-3-phenyl-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]prop-2-enamide
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(2E)-N-(3-acetylphenyl)-3-(4-nitrophenyl)prop-2-enamide
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non-competitive inhibition towards shikimate and competitive inhibition towards ATP
(2E,5Z)-5-[4-(dimethylamino)benzylidene]-2-(2-oxo-2-phenylethylidene)-1,3-thiazolidin-4-one
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uncompetitive inhibition towards shikimate and competitive inhibition towards ATP
(2R)-N-[3-chloro-4-(methylsulfonyl)benzyl]-2-hydroxy-2-(1-methyl-1H-pyrazol-4-yl)ethanamide
-
-
(3aR,6R,7R,7aS)-6,7-dihydroxy-2,2-dimethyl-3a,6,7,7a-tetrahydro-1,3-benzodioxole-4-carboxylic acid
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weak competitive reversible inhibitor
(3R,4R,5R)-3-amino-4,5-dihydroxycyclohex-1-ene-1-carboxylic acid
-
reversible competitive inhibitor
(3R,4R,5R,6R)-3,4,5,6-tetrahydroxycyclohex-1-ene-1-carboxylic acid
-
weak competitive reversible inhibitor
(3R,4S)-5-(1-benzothiophen-5-yl)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid
-
-
(3R,4S,5R)-5-(4-benzyl-1H-1,2,3-triazol-1-yl)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid
(3R,4S,5R)-5-(4-phenoxymethyl-1H-1,2,3-triazol-1-yl)-3,4-dihydroxycyclohex-1-ene-1-carboxylic acid
(3R,4S,5R)-5-bis(3-bromo-1H-indol-5-yl)methylamino-3,4-dihydroxycyclohex-1-eno-1-carboxylic acid