Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.59 extracted from

  • Allen, M.B.; Walker, D.G.
    Kinetic characterization of N-acetyl-D-glucosamine kinase from rat liver and kidney (1980), Biochem. J., 185, 577-582.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
ADP
-
Rattus norvegicus
N-acetyl-D-glucosamine inhibits phosphorylation of D-glucose Rattus norvegicus
N-acetyl-D-mannosamine inhibits phosphorylation of D-glucose Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04
-
N-acetyl-D-glucosamine enzyme from kidney, 32°C, pH 7.5 Rattus norvegicus
0.06
-
N-acetyl-D-glucosamine enzyme from liver, 32°C, pH 7.5 Rattus norvegicus
0.1
-
ATP enzyme from kidney with N-acetyl-D-glucosamine as substrate, 32°C, pH 7.5 Rattus norvegicus
0.1
-
ATP ATP in form of MgATP2- Rattus norvegicus
0.23
-
ATP enzyme from liver with N-acetyl-D-glucosamine as substrate, 32°C, pH 7.5 Rattus norvegicus
0.23
-
ATP ATP in form of MgATP2- Rattus norvegicus
0.95
-
N-acetyl-D-mannosamine enzyme from liver, 32°C, pH 7.5 Rattus norvegicus
1
-
N-acetyl-D-mannosamine enzyme from kidney, 32°C, pH 7.5 Rattus norvegicus
410
-
D-glucose enzyme from kidney, 32°C, pH 7.5 Rattus norvegicus
600
-
D-glucose enzyme from liver, 32°C, pH 7.5 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + N-acetyl-D-glucosamine Rattus norvegicus
-
ADP + N-acetyl-D-glucosamine 6-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
from liver and kidney Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-glucose
-
Rattus norvegicus ADP + D-glucose 6-phosphate
-
?
ATP + N-acetyl-D-glucosamine
-
Rattus norvegicus ADP + N-acetyl-D-glucosamine 6-phosphate
-
?
ATP + N-acetyl-D-mannosamine roughly 50% of activity Rattus norvegicus ADP + N-acetyl-D-mannosamine 6-phosphate
-
?

Subunits

Subunits Comment Organism
dimer postulated due to kinetic data Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
-
Rattus norvegicus

pH Stability

pH Stability pH Stability Maximum Comment Organism
6.2 8.5 relatively stable at pH 6.2, rapid loss of activity above pH 8.5 Rattus norvegicus