Inhibitors | Comment | Organism | Structure |
---|---|---|---|
all-trans retinoic acid | inhibits ceramide kinase transkription in neuroblastoma cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ceramide | Homo sapiens | - |
ADP + ceramide 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8TCT0 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
enzyme activity is decreased during all-trans retinoic acid-induced neuronal differentiation of SH-SY5Y cells, all-trans retinoic acid reduces CERK protein and mRNA level in a time- and concentration-dependent manner, all-trans retinoic acid reduces cellular enzyme product ceramide 1-phosphate to 60% of control cells | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ceramide | - |
Homo sapiens | ADP + ceramide 1-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ceramide kinase | - |
Homo sapiens |
CERK | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | all-trans retinoic acid inhibits ceramide kinase transkription during neuronal differentiation of a human neuroblastoma cell line SH-SY5Y, inhibition of the transcriptional activity of the 5'-promoter of ceramide kinase. Retinol does not reduce CERK protein and mRNA level | down |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme plays an important role in cellular events such as cell growth and inflammation | Homo sapiens |