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Literature summary for 2.7.1.134 extracted from

  • Wilson, M.P.; Majerus, P.W.
    Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning, and expression of the recombinant enzyme (1996), J. Biol. Chem., 271, 11904-11910.
    View publication on PubMed
Search for more literature for 2.7.1.134

Cloned(Commentary)

Cloned (Comment) Organism
expresssion in Escherichia coli Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
 x * 46000, deduced from nucleotide sequence Homo sapiens

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens Q13572
-
-

Purification (Commentary)

Purification (Comment) Organism
heparin-agarose, affinity elution with inositol hexakisphosphate, Mono Q Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
brain 0.13% of soluble protein Bos taurus
-
heart 3.6 kilobases transcript detected by Northern blot Homo sapiens
-
kidney 3.6 kilobases transcript detected by Northern blot Homo sapiens
-
liver 3.6 kilobases transcript detected by Northern blot Homo sapiens
-
liver 20fold lower amounts than in brain Bos taurus
-
lung 3.6 kilobases transcript detected by Northern blot Homo sapiens
-
pancreas 3.6 kilobases transcript detected by Northern blot Homo sapiens
-
placenta 3.6 kilobases transcript detected by Northern blot Homo sapiens
-
skeletal muscle 3.6 kilobases transcript detected by Northern blot Homo sapiens
-
skeletal muscle 200fold lower amounts than in brain Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + myo-inositol-1,3,4-trisphosphate
-
 Bos taurus ADP + myo-inositol-1,3,4,6-tetrakisphosphate
-
 ?
ATP + myo-inositol-1,3,4-trisphosphate enzyme has both inositol-1,3,4-trisphosphate 5-kinase and inositol-1,3,4-trisphosphate 6-kinase activity Homo sapiens ADP + myo-inositol-1,3,4,6-tetrakisphosphate 5:1 ratio of inositol-tetrakis-1,3,4,6-phosphate and inositol-1,2,4,5-tetrakisphosphate ?
ATP + myo-inositol-1,3,4-trisphosphate
-
 Bos taurus ADP + myo-inositol-1,3,4,5-tetrakisphosphate
-
 ?
ATP + myo-inositol-1,3,4-trisphosphate
-
 Homo sapiens ADP + myo-inositol-1,3,4,5-tetrakisphosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 46000, deduced from nucleotide sequence Homo sapiens

Synonyms

Synonyms Comment Organism
inositol 1,3,4-trisphosphate 5/6 kinase
-
 Bos taurus
inositol 1,3,4-trisphosphate 5/6 kinase
-
 Homo sapiens

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens deduced from amino acid sequence
-
 6.1