Literature summary for 2.7.1.113 extracted from

Lin, S.; Huang, C.; Sun, J.; Bollt, O.; Wang, X.; Martine, E.; Kang, J.; Taylor, M.D.; Fang, B.; Singh, P.K.; Koomen, J.; Hao, J.; Yang, S.
The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma (2019), EMBO Mol. Med., 11, e10849 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + deoxyguanosine	Homo sapiens	-	ADP + dGMP	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q16854	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
lung adenocarcinoma cell	-	Homo sapiens	-
lung adenocarcinoma cell line	human lung adenocarcinoma cell line PDC-027	Homo sapiens	-
lung adenocarcinoma cell line	human lung adenocarcinoma cell line PDC-236	Homo sapiens	-
lung adenocarcinoma cell line	human lung adenocarcinoma cell line PDC-251	Homo sapiens	-
lung squamous cell carcinoma cell	-	Homo sapiens	-
NCI-H1650 cell	-	Homo sapiens	-
NCI-H292 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + deoxyguanosine	-	Homo sapiens	ADP + dGMP	-	?

Synonyms

Synonyms	Comment	Organism
DGK	-	Homo sapiens
DGUOK	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	the depletion of the enzyme robustly inhibits lung adenocarcinoma tumor growth, metastasis, and cancer stem-like cell self-renewal	Homo sapiens
physiological function	the enzyme is required for cancer cell stemness in lung adenocarcinoma. The enzyme is required for the biogenesis of respiratory complex I and mitochondrial oxidative phosphorylation, which in turn regulates cancer stem-like cell self-renewal through AMP-activated kinase-YAP1 signaling	Homo sapiens

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Release 2023.1 (January 2023)