Literature summary for 2.7.1.107 extracted from

Hayashi, D.; Tsumagari, R.; Liu, K.; Ueda, S.; Yamanoue, M.; Sakane, F.; Shirai, Y.
Screening of subtype-specific activators and inhibitors for diacylglycerol kinase (2019), J. Biochem., 165, 517-522 .

Search for more literature for 2.7.1.107

Activating Compound

Activating Compound	Comment	Organism	Structure
4-(2,4-dimethylphenoxy)-N-hydroxybutanamide	0.1 mM KU-10 activates isoform DGKalpha by about 10%	Homo sapiens
N-[7-[cyclopropyl(hydroxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl]cyclopropanecarboxamide	0.1 mM KU-8 activates isoform DGKalpha by 19%	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in COS-7 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
N-[7-[cyclopropyl(hydroxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl]cyclopropanecarboxamide	about 10% inhibition of isoform DGKzeta at 0.1 mM; about 10% inhibition of isoform DGKzeta at 0.1 mM; about 20% inhibition of isoform DGKdelta at 0.1 mM; about 30% inhibition of isoform DGKeta at 0.1 mM; about 50% inhibition of isoform DGKbeta at 0.1 mM; about 70% inhibition of isoform DGKiota at 0.1 mM; KU-8, 0.01 mM significantly inhibits isoform DGKkappa activity by 79%, while almost complete inhibition occurs at 0.02 mM	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	-	Homo sapiens	5886	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O75912	-	-
Homo sapiens	P23743	-	-
Homo sapiens	P49619	-	-
Homo sapiens	P52824	-	-
Homo sapiens	Q13574	-	-
Homo sapiens	Q16760	-	-
Homo sapiens	Q5KSL6	-	-
Homo sapiens	Q86XP1	-	-
Homo sapiens	Q9Y6T7	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol	-	Homo sapiens	ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
DGKalpha	isoform	Homo sapiens
DGKbeta	isoform	Homo sapiens
DGKdelta	isoform	Homo sapiens
DGKeta	isoform	Homo sapiens
DGKgamma	isoform	Homo sapiens
DGKiota	isoform	Homo sapiens
DGKkappa	isoform	Homo sapiens
DGKtheta	isoform	Homo sapiens
DGKzeta	isoform	Homo sapiens

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Release 2023.1 (January 2023)