Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.107 extracted from

  • Epand, R.M.; So, V.; Jennings, W.; Khadka, B.; Gupta, R.S.; Lemaire, M.
    Diacylglycerol kinase-epsilon properties and biological roles (2016), Front. Cell Dev. Biol., 4, 112 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.107

Inhibitors

Inhibitors Comment Organism Structure
phosphatidylinositol-4,5-bisphosphate noncompetitive inhibitor with respect to 1-stearoyl-2-arachidonoyl-sn-glycerol but a competitive inhibitor with respect to ATP Homo sapiens
R59022
-
 Homo sapiens
R59949
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane
-
 Homo sapiens 5789
-
plasma membrane
-
 Homo sapiens 5886
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P52429
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
heart
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol specific substrate of isoform DGKepsilon Homo sapiens ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
 ?
ATP + 1-stearoyl-2-linoleoyl-sn-glycerol
-
 Homo sapiens ADP + 1-stearoyl-2-linoleoyl-sn-glycerol 3-phosphate
-
 ?
additional information isoform DGKepsilon is unable to phosphorylate 1-stearoyl-2-docosahexaenoyl-sn-glycerol and has essentially no activity in phosphorylating 1-monoacylglycerol substrates Homo sapiens ?
-
-

Synonyms

Synonyms Comment Organism
DGKepsilon
-
 Homo sapiens
diacylglycerol kinase-epsilon
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction recessive loss of function mutations in isoform DGKepsilon cause atypical hemolytic-uremic syndrome Homo sapiens
metabolism 1-stearoyl-2-arachidonoyl-sn-glycerol phosphorylation to phosphatidic acid catalyzed by isoform DGKepsilon is one of the key steps of the phosphoinositide cycle. Enhanced isoform DGKepsilon activity plays a role in Huntingtons disease pathogenesis Homo sapiens