Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phorbol-12-myristate-13-acetate | diacylglycerol kinase zeta activity at the T cell receptor is enhanced by phorbol-12-myristate-13-acetate cotreatment | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | at early stages of T cell immunological synapse formation, isoform zeta translocates rapidly to the plasma membrane | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P23743 | isoform diacalglycerol kinase alpha | - |
Homo sapiens | Q13574 | isoform diacalglycerol kinase zeta | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JURKAT cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | endogenous isoform diacylglycerol kinase alpha is recruited to the T cell receptor complex following T cell receptor/CD28 engagement | Homo sapiens |
physiological function | endogenous isoform diacylglycerol kinase zeta is recruited to the T cell receptor complex following T cell receptor/CD28 engagement. Specific diacylglycerol kinase gene silencing shows that phosphatidic acid production at the activated complex depends mainly on diacylglycerol kinase zeta. At early stages of T cell immunological synapse formation, isoform zeta translocates rapidly to the plasma membrane, where rapid, sustained diacylglycerol accumulation is found | Homo sapiens |