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Literature summary for 2.7.1.107 extracted from

  • Gharbi, S.I.; Rincon, E.; Avila-Flores, A.; Torres-Ayuso, P.; Almena, M.; Cobos, M.A.; Albar, J.P.; Merida, I.
    Diacylglycerol kinase zeta controls diacylglycerol metabolism at the immunological synapse (2011), Mol. Biol. Cell, 22, 4406-4414.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
phorbol-12-myristate-13-acetate diacylglycerol kinase zeta activity at the T cell receptor is enhanced by phorbol-12-myristate-13-acetate cotreatment Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane at early stages of T cell immunological synapse formation, isoform zeta translocates rapidly to the plasma membrane Homo sapiens 16020
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Organism

Organism UniProt Comment Textmining
Homo sapiens P23743 isoform diacalglycerol kinase alpha
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Homo sapiens Q13574 isoform diacalglycerol kinase zeta
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Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
Homo sapiens
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General Information

General Information Comment Organism
physiological function endogenous isoform diacylglycerol kinase alpha is recruited to the T cell receptor complex following T cell receptor/CD28 engagement Homo sapiens
physiological function endogenous isoform diacylglycerol kinase zeta is recruited to the T cell receptor complex following T cell receptor/CD28 engagement. Specific diacylglycerol kinase gene silencing shows that phosphatidic acid production at the activated complex depends mainly on diacylglycerol kinase zeta. At early stages of T cell immunological synapse formation, isoform zeta translocates rapidly to the plasma membrane, where rapid, sustained diacylglycerol accumulation is found Homo sapiens