Cloned (Comment) | Organism |
---|---|
expressed in COS-7 cells and in baculovirus-infected Sf21 insect cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2-diarachidonoyl phosphatidic acid | about 55% relative activity in the presence of 1.5 mol% | Homo sapiens | |
1-arachidoyl-2-arachidonoyl phosphatidic acid | about 70% relative activity in the presence of 1.5 mol% | Homo sapiens | |
1-palmitoyl-2-arachidonoyl phosphatidic acid | about 50% relative activity in the presence of 1.5 mol% | Homo sapiens | |
1-stearoyl-2-arachidonoyl phosphatidic acid | about 48% relative activity in the presence of 1.5 mol% | Homo sapiens | |
1-stearoyl-2-oleoyl phosphatidic acid | about 70% relative activity in the presence of 1.5 mol% | Homo sapiens | |
phosphatidic acid | competitive inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P52429 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-dioleoyl-sn-glycerol | isoform DGKepsilon shows about 7% activity with 0.38 mol% 1,2-dioleoyl-sn-glycerol compared to 1-stearoyl-2-arachidonoyl-sn-glycerol | Homo sapiens | ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1-arachidoyl-2-arachidonoyl-sn-glycerol | isoform DGKepsilon shows about 70% activity with 0.38 mol% 1-arachidoyl-2-arachidonoyl-sn-glycerol compared to 1-stearoyl-2-arachidonoyl-sn-glycerol | Homo sapiens | ADP + ? | - |
? | |
ATP + 1-palmitoyl-2-arachidonoyl-sn-glycerol | isoform DGKepsilon shows about 90% activity with 0.38 mol% 1-palmitoyl-2-arachidonoyl-sn-glycerol compared to 1-stearoyl-2-arachidonoyl-sn-glycerol | Homo sapiens | ADP + 1-palmitoyl-2-arachidonoyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol | isoform DGKepsilon shows 100% activity with 0.38 mol% 1-stearoyl-2-arachidonoyl-sn-glycerol | Homo sapiens | ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 2-arachidonoyl-sn-glycerol | isoform DGKepsilon shows substrate specificity for sn-2 arachidonoyl-diacylglycerol | Homo sapiens | ADP + 2-arachidonoyl-sn-glycerol 3-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DGKepsilon | - |
Homo sapiens |
diacylglycerol kinase epsilon | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |