Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.107 extracted from

  • Lung, M.; Shulga, Y.V.; Ivanova, P.T.; Myers, D.S.; Milne, S.B.; Brown, H.A.; Topham, M.K.; Epand, R.M.
    Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerol (2009), J. Biol. Chem., 284, 31062-31073.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells and in baculovirus-infected Sf21 insect cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,2-diarachidonoyl phosphatidic acid about 55% relative activity in the presence of 1.5 mol% Homo sapiens
1-arachidoyl-2-arachidonoyl phosphatidic acid about 70% relative activity in the presence of 1.5 mol% Homo sapiens
1-palmitoyl-2-arachidonoyl phosphatidic acid about 50% relative activity in the presence of 1.5 mol% Homo sapiens
1-stearoyl-2-arachidonoyl phosphatidic acid about 48% relative activity in the presence of 1.5 mol% Homo sapiens
1-stearoyl-2-oleoyl phosphatidic acid about 70% relative activity in the presence of 1.5 mol% Homo sapiens
phosphatidic acid competitive inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P52429
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1,2-dioleoyl-sn-glycerol isoform DGKepsilon shows about 7% activity with 0.38 mol% 1,2-dioleoyl-sn-glycerol compared to 1-stearoyl-2-arachidonoyl-sn-glycerol Homo sapiens ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate
-
?
ATP + 1-arachidoyl-2-arachidonoyl-sn-glycerol isoform DGKepsilon shows about 70% activity with 0.38 mol% 1-arachidoyl-2-arachidonoyl-sn-glycerol compared to 1-stearoyl-2-arachidonoyl-sn-glycerol Homo sapiens ADP + ?
-
?
ATP + 1-palmitoyl-2-arachidonoyl-sn-glycerol isoform DGKepsilon shows about 90% activity with 0.38 mol% 1-palmitoyl-2-arachidonoyl-sn-glycerol compared to 1-stearoyl-2-arachidonoyl-sn-glycerol Homo sapiens ADP + 1-palmitoyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
?
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol isoform DGKepsilon shows 100% activity with 0.38 mol% 1-stearoyl-2-arachidonoyl-sn-glycerol Homo sapiens ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
?
ATP + 2-arachidonoyl-sn-glycerol isoform DGKepsilon shows substrate specificity for sn-2 arachidonoyl-diacylglycerol Homo sapiens ADP + 2-arachidonoyl-sn-glycerol 3-phosphate
-
?

Synonyms

Synonyms Comment Organism
DGKepsilon
-
Homo sapiens
diacylglycerol kinase epsilon
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens