General Stability | Organism |
---|---|
DGKalpha is also activated when it binds to membranes | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phosphatidylinositol 4,5-bisphosphate | potent inhibitor | Mus musculus | |
phosphatidylinositol-(4,5)-bisphosphate | potent inhibitor; potent inhibitor | Mus musculus | |
R59949 | DGKalpha inhibitor | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | in the basal state, DGKzeta resides in the cytoplasm, but upon appropriate cellular events, it translocates to different parts of the cell in order to perform its biological role | Mus musculus | 5737 | - |
cytoskeleton | - |
Mus musculus | 5856 | - |
nucleus | - |
Mus musculus | 5634 | - |
plasma membrane | - |
Mus musculus | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activates | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
64000 | - |
isoform DGKepsilon | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O88673 | DGKalpha isoform | - |
Mus musculus | Q80UP3 | DGKzeta isoform | - |
Mus musculus | Q9R1C6 | DGKepsilon isoform | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-diacylglycerol | - |
Mus musculus | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1,2-diacylglycerol | DGKepsilon exhibits specificity for diacylglcerol substrates containing an arachidonoyl chain in the sn-2 position | Mus musculus | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DGKalpha | isoform | Mus musculus |
DGKepsilon | isoform | Mus musculus |
DGKzeta | isoform | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | DGKalpha has a central role in modulating T cell anergy through its ability to control DAG levels, which likely activates RasGRP1 and possibly other proteins | Mus musculus |
physiological function | DGKzeta has an important biological function in the nucleus where it appears to modulate the cell cycle by metabolizing 1,2-diacylglycerol | Mus musculus |