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Literature summary for 2.7.1.107 extracted from

  • Topham, M.K.; Epand, R.M.
    Mammalian diacylglycerol kinases: molecular interactions and biological functions of selected isoforms (2009), Biochim. Biophys. Acta, 1790, 416-424.
    View publication on PubMedView publication on EuropePMC

General Stability

General Stability Organism
DGKalpha is also activated when it binds to membranes Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
phosphatidylinositol 4,5-bisphosphate potent inhibitor Mus musculus
phosphatidylinositol-(4,5)-bisphosphate potent inhibitor; potent inhibitor Mus musculus
R59949 DGKalpha inhibitor Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm in the basal state, DGKzeta resides in the cytoplasm, but upon appropriate cellular events, it translocates to different parts of the cell in order to perform its biological role Mus musculus 5737
-
cytoskeleton
-
Mus musculus 5856
-
nucleus
-
Mus musculus 5634
-
plasma membrane
-
Mus musculus 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
64000
-
isoform DGKepsilon Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus O88673 DGKalpha isoform
-
Mus musculus Q80UP3 DGKzeta isoform
-
Mus musculus Q9R1C6 DGKepsilon isoform
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1,2-diacylglycerol
-
Mus musculus ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
ATP + 1,2-diacylglycerol DGKepsilon exhibits specificity for diacylglcerol substrates containing an arachidonoyl chain in the sn-2 position Mus musculus ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?

Synonyms

Synonyms Comment Organism
DGKalpha isoform Mus musculus
DGKepsilon isoform Mus musculus
DGKzeta isoform Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus

General Information

General Information Comment Organism
physiological function DGKalpha has a central role in modulating T cell anergy through its ability to control DAG levels, which likely activates RasGRP1 and possibly other proteins Mus musculus
physiological function DGKzeta has an important biological function in the nucleus where it appears to modulate the cell cycle by metabolizing 1,2-diacylglycerol Mus musculus