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Literature summary for 2.7.1.107 extracted from

  • Merida, I.; Avila-Flores, A.; Garcia, J.; Merino, E.; Almena, M.; Torres-Ayuso, P.
    Diacylglycerol kinase alpha, from negative modulation of T cell activation to control of cancer progression (2009), Adv. Enzyme Regul., 49, 174-188.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cholesterol DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such cholesterol Homo sapiens
cholesterol DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such cholesterol Mus musculus
P53 p53 activates DGKalpha in response to DNA damage Homo sapiens
P53 p53 activates DGKalpha in response to DNA damage Mus musculus
phosphatidylethanolamine DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such as phosphatidylethanolamine Homo sapiens
phosphatidylethanolamine DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such as phosphatidylethanolamine Mus musculus

General Stability

General Stability Organism
activation of tyrosine kinases is required for membrane stabilization of DGKalpha, phosphorylation of DGKalpha at Tyr335 appears to be essential for membrane localization Homo sapiens
activation of tyrosine kinases is required for membrane stabilization of DGKalpha, phosphorylation of DGKalpha at Tyr335 appears to be essential for membrane localization Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function Homo sapiens 5829
-
cytosol DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function Mus musculus 5829
-
membrane DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function Homo sapiens 16020
-
membrane DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function Mus musculus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+ requirement in DGKalpha activation Homo sapiens
Ca2+ Ca2+ requirement in DGKalpha activation Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens P23743
-
-
Mus musculus O88673
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain high expression Mus musculus
-
endothelial cell
-
Homo sapiens
-
endothelial cell
-
Mus musculus
-
heart low expression Mus musculus
-
kidney low expression Mus musculus
-
liver low expression Mus musculus
-
lung high expression Mus musculus
-
oligodendrocyte DGKalpha is expressed predominantly in oligodendrocytes Homo sapiens
-
oligodendrocyte DGKalpha is expressed predominantly in oligodendrocytes Mus musculus
-
spleen high expression Mus musculus
-
T-lymphocyte particularly enriched in peripheral T lymphocytes Homo sapiens
-
T-lymphocyte particularly enriched in peripheral T lymphocytes Mus musculus
-
testis high expression Mus musculus
-
thymus particularly enriched in thymus Homo sapiens
-
thymus particularly enriched in thymus Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1,2-diacylglycerol
-
Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
ATP + 1,2-diacylglycerol
-
Mus musculus ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?

Synonyms

Synonyms Comment Organism
DGKalpha isoform Homo sapiens
DGKalpha isoform Mus musculus
diacylglycerol kinase alpha isoform Homo sapiens
diacylglycerol kinase alpha isoform Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
ATP
-
Mus musculus

Expression

Organism Comment Expression
Homo sapiens p53-mediated upregulation of DGKalpha mRNA in human-derived cells, (PPAR)-gamma-dependent DGKalpha upregulation in endothelial cells, DMSO-based differentiation of promyelocytic HL-60 cells into a neutrophilic phenotype correlates with increase in the expression of DGKalpha, DGKalpha expression is upregulated in cancer up
Mus musculus p53-mediated upregulation of DGKalpha mRNA in mouse-derived cells, (PPAR)-gamma-dependent DGKalpha upregulation in endothelial cells, DMSO-based differentiation of promyelocytic HL-60 cells into a neutrophilic phenotype correlates with increase in the expression of DGKalpha, DGKalpha expression is upregulated in cancer up

General Information

General Information Comment Organism
physiological function membrane localization of DGKalpha acts as a switch-off signal for Ras activation, mediated by localization to the membrane of Ras-GRP1, DGKalpha is a negative regulator of the T cell activation program, DGKalpha activity is required for optimal chemotactic response of neutrophils, whereas it halts their oxidative burst, DGKalpha is a negative modulator of diacylglycerol signaling, DGKalpha activity modulates the mTOR pathway to prevent cell cycle transition, DGKalpha is an indicator of cell quiescence, DGKalpha is a positive regulator of cell proliferation and migration Homo sapiens
physiological function membrane localization of DGKalpha acts as a switch-off signal for Ras activation, mediated by localization to the membrane of Ras-GRP1, DGKalpha is a negative regulator of the T cell activation program, DGKalpha activity is required for optimal chemotactic response of neutrophils, whereas it halts their oxidative burst, DGKalpha is a negative modulator of diacylglycerol signaling, DGKalpha activity modulates the mTOR pathway to prevent cell cycle transition, DGKalpha is an indicator of cell quiescence, DGKalpha is a positive regulator of cell proliferation and migration Mus musculus