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Literature summary for 2.7.1.107 extracted from

  • Chianale, F.; Cutrupi, S.; Rainero, E.; Baldanzi, G.; Porporato, P.E.; Traini, S.; Filigheddu, N.; Gnocchi, V.F.; Santoro, M.M.; Parolini, O.; van Blitterswijk, W.J.; Sinigaglia, F.; Graziani, A.
    Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling (2007), Mol. Biol. Cell, 18, 4859-4871.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
G434D kinase-defective dominant-negative mutant , impairs hepatocyte growth factor- and v-Src-induced cell scatter and migration, without affecting the loss of intercellular adhesions, impairs hepatocyre growth factor-induced cell spreading, lamellipodia formation, membrane ruffling, and focal adhesions remodeling and impairs hepatocyte growth factor-induced Rac activation and membrane targeting Canis lupus familiaris
additional information downregulation of diacylglycerol kinase alpha by siRNA impairs hepatocyte growth factor- and v-Src-induced cell scatter and migration, without affecting the loss of intercellular adhesions, impairs hepatocyre growth factor-induced cell spreading, lamellipodia formation, membrane ruffling, and focal adhesions remodeling and impairs hepatocyte growth factor-induced Rac activation and membrane targeting Canis lupus familiaris

Inhibitors

Inhibitors Comment Organism Structure
R59949 specific inhibition of diacylglycerol kinase alpha. Inhibition impairs impairs hepatocyte growth factor- and v-Src-induced cell scatter and migration, without affecting the loss of intercellular adhesions, impairs hepatocyre growth factor-induced cell spreading, lamellipodia formation, membrane ruffling, and focal adhesions remodeling and impairs hepatocyte growth factor-induced Rac activation and membrane targeting Canis lupus familiaris

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
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Source Tissue

Source Tissue Comment Organism Textmining
MDCK cell
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Canis lupus familiaris
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