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Literature summary for 2.7.1.107 extracted from

  • Epand, R.M.; Shulga, Y.V.; Timmons, H.C.; Perri, A.L.; Belani, J.D.; Perinpanathan, K.; Johnson-McIntire, L.B.; Bajjalieh, S.; Dicu, A.O.; Elias, C.; Rychnovsky, S.D.; Topham, M.K.
    Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase (2007), Biochemistry, 46, 14225-14231.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in SF21 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,3-dioleoylglycerol uncompetitive inhibition of isoforms diacylglycerol kinase alpha and zeta, no inhibition of isoform epsilon. Binds to a site on the alpha and zeta isoforms that is exposed as a consequence of the substrate binding to the active site, the chiral specificity of the isoforms thus mimicks the substrate specificity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Km value in mol% for substrate 1,2-dioleoylglycerol is 0.8 for isoform alpha, 0.52 for isoform zeta, pH 7.2, 30°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ isoform diacylglycerol kinase alpha requires Ca2+ Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1,2-dioleoyl-sn-glycerol
-
Homo sapiens ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate
-
?
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol preferred substrate of isoform diacylglycerol kinase epsilon Homo sapiens ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
?
ATP + 2,3-dioleoyl-sn-glycerol
-
Homo sapiens ADP + 2,3-diacyl-sn-glycerol 1-phosphate isoform diacylglycerol kinase alpha 8.5%, zeta, 12%, epsilon 6% of the activity with 1,2-dioleoyl-sn-glycerol, respectively ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information Ki value in mol% for inhibitor 2,3-dioleoylglycerol is 1.7 for isoform alpha, 1.07 for isoform zeta, pH 7.2, 30°C Homo sapiens