Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | DGKeta1 and DGKeta2 are rapidly translocated from the cytoplasm to endosomes in response to stress stimuli. DGKeta1 is rapidly relocated back to the cytoplasm upon removal of stress stimuli. DGKeta2 exhibits sustained endosomal association | Homo sapiens | 5737 | - |
endosome | DGKeta1 and DGKeta2 are rapidly translocated from the cytoplasm to endosomes in response to stress stimuli. DGKeta1 is rapidly relocated back to the cytoplasm upon removal of stress stimuli. DGKeta2 exhibits sustained endosomal association. Oligomerization of DGKeta2 mediated by its SAM domain is largely responsible for its sustained endosomal localization | Homo sapiens | 5768 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
128000 | - |
x * 128000 DGKeta1, calculation from nucleotide sequence | Homo sapiens |
135000 | - |
x * 135000, DGKeta2, calculation from nucleotide sequence | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-diacyl-sn-glycerol | Homo sapiens | the expression of DGKeta2 is suppressed by glucocorticoid in contrast to the marked induction of DGKeta1 | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q86XP1 | DGKeta1 and DGKeta2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | DGKeta1 | Homo sapiens | - |
colon | DGKeta1 and DGKeta2 | Homo sapiens | - |
kidney | DGKeta1 and DGKeta2 | Homo sapiens | - |
liver | DGKeta1 | Homo sapiens | - |
additional information | DGKeta1 is ubiquitously distributed in various tissues, DGKeta2 is detected only in testis, kidney and colon | Homo sapiens | - |
ovary | DGKeta1 | Homo sapiens | - |
pancreas | DGKeta1 | Homo sapiens | - |
peripheral blood | DGKeta1 | Homo sapiens | - |
prostate | DGKeta1 | Homo sapiens | - |
small intestine | DGKeta1 | Homo sapiens | - |
spleen | DGKeta1 | Homo sapiens | - |
testis | DGKeta1 and DGKeta2 | Homo sapiens | - |
thymus | DGKeta1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-diacyl-sn-glycerol | the expression of DGKeta2 is suppressed by glucocorticoid in contrast to the marked induction of DGKeta1 | Homo sapiens | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 128000 DGKeta1, calculation from nucleotide sequence | Homo sapiens |
? | x * 135000, DGKeta2, calculation from nucleotide sequence | Homo sapiens |