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Literature summary for 2.7.1.107 extracted from

  • Murakami, T.; Sakane, F.; Imai, S.; Houkin, K.; Kanoh, H.
    Identification and characterization of two splice variants of human diacylglycerol kinase eta (2003), J. Biol. Chem., 278, 34364-34372.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm DGKeta1 and DGKeta2 are rapidly translocated from the cytoplasm to endosomes in response to stress stimuli. DGKeta1 is rapidly relocated back to the cytoplasm upon removal of stress stimuli. DGKeta2 exhibits sustained endosomal association Homo sapiens 5737
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endosome DGKeta1 and DGKeta2 are rapidly translocated from the cytoplasm to endosomes in response to stress stimuli. DGKeta1 is rapidly relocated back to the cytoplasm upon removal of stress stimuli. DGKeta2 exhibits sustained endosomal association. Oligomerization of DGKeta2 mediated by its SAM domain is largely responsible for its sustained endosomal localization Homo sapiens 5768
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
128000
-
x * 128000 DGKeta1, calculation from nucleotide sequence Homo sapiens
135000
-
x * 135000, DGKeta2, calculation from nucleotide sequence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1,2-diacyl-sn-glycerol Homo sapiens the expression of DGKeta2 is suppressed by glucocorticoid in contrast to the marked induction of DGKeta1 ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86XP1 DGKeta1 and DGKeta2
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Source Tissue

Source Tissue Comment Organism Textmining
brain DGKeta1 Homo sapiens
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colon DGKeta1 and DGKeta2 Homo sapiens
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kidney DGKeta1 and DGKeta2 Homo sapiens
-
liver DGKeta1 Homo sapiens
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additional information DGKeta1 is ubiquitously distributed in various tissues, DGKeta2 is detected only in testis, kidney and colon Homo sapiens
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ovary DGKeta1 Homo sapiens
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pancreas DGKeta1 Homo sapiens
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peripheral blood DGKeta1 Homo sapiens
-
prostate DGKeta1 Homo sapiens
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small intestine DGKeta1 Homo sapiens
-
spleen DGKeta1 Homo sapiens
-
testis DGKeta1 and DGKeta2 Homo sapiens
-
thymus DGKeta1 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1,2-diacyl-sn-glycerol the expression of DGKeta2 is suppressed by glucocorticoid in contrast to the marked induction of DGKeta1 Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?

Subunits

Subunits Comment Organism
? x * 128000 DGKeta1, calculation from nucleotide sequence Homo sapiens
? x * 135000, DGKeta2, calculation from nucleotide sequence Homo sapiens