Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.6.1.88 extracted from

  • Tavares, C.D.J.; Sharabi, K.; Dominy, J.E.; Lee, Y.; Isasa, M.; Orozco, J.M.; Jedrychowski, M.P.; Kamenecka, T.M.; Griffin, P.R.; Gygi, S.P.; Puigserver, P.
    The methionine transamination pathway controls hepatic glucose metabolism through regulation of the GCN5 acetyltransferase and the PGC-1alpha transcriptional coactivator (2016), J. Biol. Chem., 279, 10635-10645 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.6.1.88

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57BL/6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Mus musculus
-
liver
-
 Mus musculus
-

General Information

General Information Comment Organism
metabolism methionine transamination provides a route for the degradation and clearance of methionine. In addition to the transmethylation and transsulfuration pathways, methionine is also shunted down the transamination pathway. Methionine flux down the transamination pathway leads to activation of the GCN5 acetyltransferase. This promotes PGC-1 acetylation and inhibition, leading to the suppression of hepatic glucose production Mus musculus
physiological function methionine, through its metabolism via the transamination pathway, is able to potently suppress the PGC-1alpha-mediated hepatic gluconeogenic program in vitro. Methionine administration in vivo decreased Ppargc1a expression Mus musculus