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Literature summary for 2.6.1.7 extracted from

  • Han, Q.; Cai, T.; Tagle, D.A.; Robinson, H.; Li, J.
    Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II (2008), Biosci. Rep., 28, 205-215.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
KAT II complex with 2-oxoglutarate, hanging drop vapor diffusion method Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-hydroxykynurenine less than 35% inhibition at 5 mM Homo sapiens
aminoadipate less than 35% inhibition at 5 mM Homo sapiens
L-asparagine less than 35% inhibition at 5 mM Homo sapiens
L-cysteine less than 35% inhibition at 5 mM Homo sapiens
L-glutamate less than 35% inhibition at 5 mM Homo sapiens
L-histidine less than 35% inhibition at 5 mM Homo sapiens
L-lysine less than 35% inhibition at 5 mM Homo sapiens
L-phenylalanine less than 35% inhibition at 5 mM Homo sapiens
additional information not inhibited by glyoxylate Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2
-
2-oxoglutarate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
1.4
-
indo-3-pyruvate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
1.5
-
2-oxocaproate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
1.5
-
hydroxyphenylpyruvate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
1.8
-
phenylpyruvate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
2.4
-
2-oxo-4-methylthiobutyrate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
2.8
-
Mercaptopyruvate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
3.3
-
4-methyl-2-oxopentanoate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
3.4
-
2-oxovalerate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
4.7
-
L-kynurenine in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
9.7
-
pyruvate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
12.7
-
2-oxobutyrate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
12.9
-
3-methyl-2-oxobutanoate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
14.2
-
3-methyl-2-oxobutanoate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
16.8
-
oxaloacetate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
18
-
glyoxylate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
20.9
-
2-oxoadipate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N5Z0
-
-

Purification (Commentary)

Purification (Comment) Organism
DEAE-Sepharose column chromatography, hydroxyapatite column chromatography, and gel filtration Homo sapiens

Storage Stability

Storage Stability Organism
-80°C, isolated KAT II, no noticeable decrease in specific activity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + 2-oxo-4-methylthiobutyrate
-
Homo sapiens ?
-
?
L-kynurenine + 2-oxoadipate
-
Homo sapiens ?
-
?
L-kynurenine + 2-oxobutyrate
-
Homo sapiens kynurenic acid + 2-aminobutanoate + H2O
-
?
L-kynurenine + 2-oxocaproate
-
Homo sapiens ?
-
?
L-kynurenine + 2-oxoglutarate
-
Homo sapiens kynurenic acid + L-glutamate + H2O
-
?
L-kynurenine + 2-oxovalerate
-
Homo sapiens ?
-
?
L-kynurenine + 3-methyl-2-oxobutanoate
-
Homo sapiens ?
-
?
L-kynurenine + 3-methyl-2-oxopentanoate
-
Homo sapiens ?
-
?
L-kynurenine + 4-methyl-2-oxopentanoate
-
Homo sapiens ?
-
?
L-kynurenine + glyoxylate glyoxylate shows a relatively low affinity for KAT II Homo sapiens 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
-
?
L-kynurenine + hydroxyphenylpyruvate
-
Homo sapiens ?
-
?
L-kynurenine + indo-3-pyruvate
-
Homo sapiens ?
-
?
L-kynurenine + mercaptopyruvate
-
Homo sapiens ?
-
?
L-kynurenine + oxaloacetate
-
Homo sapiens ?
-
?
L-kynurenine + phenylpyruvate
-
Homo sapiens ?
-
?
L-kynurenine + pyruvate
-
Homo sapiens ?
-
?
additional information 2-oxoglutarate, 2-oxocaproate, phenylpyruvate, and 2-oxo-4-methylthiobutyrate are highly efficient as amino-group acceptors for KAT II Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
KAT II
-
Homo sapiens
kynurenine aminotransferase II
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
50
-
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.065
-
oxaloacetate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.36
-
pyruvate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.39
-
hydroxyphenylpyruvate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.92
-
3-methyl-2-oxobutanoate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.92
-
3-methyl-2-oxopentanoate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
1.49
-
indo-3-pyruvate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
2.51
-
4-methyl-2-oxopentanoate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
2.66
-
2-oxovalerate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
3.49
-
2-oxobutyrate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
3.59
-
Mercaptopyruvate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
3.64
-
glyoxylate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
4.27
-
2-oxo-4-methylthiobutyrate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
4.73
-
phenylpyruvate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
4.83
-
2-oxocaproate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
4.84
-
2-oxoadipate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
7.67
-
2-oxoglutarate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
9.76
-
L-kynurenine in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
7 9
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.04
-
pyruvate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.065
-
3-methyl-2-oxopentanoate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.07
-
3-methyl-2-oxobutanoate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.09
-
oxaloacetate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.2
-
glyoxylate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.23
-
2-oxoadipate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.27
-
2-oxobutyrate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.27
-
hydroxyphenylpyruvate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.76
-
4-methyl-2-oxopentanoate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
0.78
-
2-oxovalerate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
1.08
-
indo-3-pyruvate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
1.23
-
Mercaptopyruvate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
1.75
-
2-oxo-4-methylthiobutyrate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
2.62
-
phenylpyruvate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
3.13
-
2-oxocaproate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
3.27
-
L-kynurenine in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens
6.24
-
2-oxoglutarate in 100 mM potassium phosphate buffer (pH 7.4), at 37°C Homo sapiens