Application | Comment | Organism |
---|---|---|
medicine | S-adenosyl-L-methionine is applied to patients with alcoholic liver disease | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | feedback inhibition of isozyme MAT II | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | different isoforms of MAT differ in kinetic and regulatory properties, overview | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | - |
Homo sapiens | |
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-methionine + H2O | Homo sapiens | an essential enzyme that catalyzes the formation of the principal methyl donor S-adenosylmethionine, S-adenosyl-L-methionine is also a key metabolite that regulates hepatocyte growth, death and differentiation, molecular mechanism, overview, abnormalities in MAT and decreased S-adenosyl-L-methionine levels occur in humans with alcoholic liver disease, chronic hepatic S-adenosyl-L-methionine deficiency can result in the spontaneous development of steatohepatitis and hepatocellular carcinoma, overview, hepatic S-adenosyl-L-methionine biosynthesis and methionine metabolism, overview | phosphate + diphosphate + S-adenosyl-L-methionine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
genes MAT1A and MAT2A, isozymes MAT I-MAT III | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | in cultured hepatocytes MAT1A expression falls and MAT2A is induced when S-adenosyl-L-methionine level falls, which can be prevented by exogenous S-adenosyl-L-methionine | Homo sapiens | - |
liver | expression of MAT1A, a marker for differentiated liver, MAT1A progressively replaces MAT2A, which is mainly expressed in fetal liver | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-methionine + H2O | - |
Homo sapiens | phosphate + diphosphate + S-adenosyl-L-methionine | - |
? | |
ATP + L-methionine + H2O | an essential enzyme that catalyzes the formation of the principal methyl donor S-adenosylmethionine, S-adenosyl-L-methionine is also a key metabolite that regulates hepatocyte growth, death and differentiation, molecular mechanism, overview, abnormalities in MAT and decreased S-adenosyl-L-methionine levels occur in humans with alcoholic liver disease, chronic hepatic S-adenosyl-L-methionine deficiency can result in the spontaneous development of steatohepatitis and hepatocellular carcinoma, overview, hepatic S-adenosyl-L-methionine biosynthesis and methionine metabolism, overview | Homo sapiens | phosphate + diphosphate + S-adenosyl-L-methionine | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | genes MAT1A and MAT2A encode catalytic subunits alpha1 and alpha2, respectively, the subunits differentially build the isozymes together with a regulatory beta subunit, isozyme composition, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
MAT | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |