Literature summary for 2.5.1.29 extracted from

Wang, X.; Xu, W.; Zhan, P.; Xu, T.; Jin, J.; Miu, Y.; Zhou, Z.; Zhu, Q.; Wan, B.; Xi, G.; Ye, L.; Liu, Y.; Gao, J.; Li, H.; Lv, T.; Song, Y.
Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma (2018), J. Cell. Mol. Med., 22, 2177-2189 .

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Application

Application	Comment	Organism
diagnostics	overexpression of geranylgeranyl diphosphate synthase correlates with poor prognosis of lung adenocarcinoma and contributes to metastasis through regulating epithelial-mesenchymal transition	Homo sapiens
medicine	enzyme expression is significantly increased in lung adenocarcinoma tissues compared to that in adjacent normal tissues. Overexpression of geranylgeranyl diphosphate synthase is correlated with large tumours, high TNM stage, lymph node metastasis and poor prognosis in patients	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O95749	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
PC-9 cell	-	Homo sapiens	-
SPCA-1 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
GGPPS	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	the enzyme is down-regulated in SPCA-1, PC9 and A549 cells using siRNA	down
Homo sapiens	enzyme expression is significantly increased in lung adenocarcinoma tissues compared to that in adjacent normal tissues	up
Homo sapiens	overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma	up
Homo sapiens	the enzyme is up-regulated in A549 cells using an adenoviral vector	up

General Information

General Information	Comment	Organism
malfunction	knockdown of geranylgeranyl diphosphate synthase inhibits the migration and invasion of lung adenocarcinoma cells, but does not affect cell proliferation and apoptosis. Geranylgeranyl diphosphate synthase inhibition significantly increases the expression of E-cadherin and reduces the expression of N-cadherin and vimentin in lung adenocarcinoma cells. In addition, the Rac1/Cdc42 geranylgeranylation is reduced by geranylgeranyl diphosphate synthase knockdown	Homo sapiens

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Release 2023.1 (January 2023)