Literature summary for 2.4.3.3 extracted from

Marcos, N.T.; Cruz, A.; Silva, F.; Almeida, R.; David, L.; Mandel, U.; Clausen, H.; von Mensdorff-Pouilly, S.; Reis, C.A.
Polypeptide GalNAc-transferases, ST6GalNAc-transferase I, and ST3Gal-transferase I expression in gastric carcinoma cell lines (2003), J. Histochem. Cytochem., 51, 761-771.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein	Homo sapiens	ST6GalNAc-I is responsible for the synthesis of Sialyl-Tn antigen, Neu5Acalpha(2-6)GalNAc, synthesis of Sialyl-Tn structures in mucin O-glycosylation stops further processing and elongation of the carbohydrate chain	CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	ST6GalNAc-I	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
K-562 cell	hematopoietic cell line, high ST6GalNAc-I expression	Homo sapiens	-
additional information	low expression of ST6GalNAc-I in gastric carcinoma cell lines MKN45, KATO-III, GP202 and GP220, correlating with very low or absent detection of the Sialyl-Tn antigen	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein	ST6GalNAc-I is responsible for the synthesis of Sialyl-Tn antigen, Neu5Acalpha(2-6)GalNAc, synthesis of Sialyl-Tn structures in mucin O-glycosylation stops further processing and elongation of the carbohydrate chain	Homo sapiens	CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein	-	?
CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein	-	Homo sapiens	CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein	-	?

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Release 2023.1 (January 2023)