Literature summary for 2.4.3.1 extracted from

Hsieh, C.C.; Shyr, Y.M.; Liao, W.Y.; Chen, T.H.; Wang, S.E.; Lu, P.C.; Lin, P.Y.; Chen, Y.B.; Mao, W.Y.; Han, H.Y.; Hsiao, M.; Yang, W.B.; Li, W.S.; Sher, Y.P.; Shen, C.N.
Elevation of beta-galactoside alpha2,6-sialyltransferase 1 in a fructoseresponsive manner promotes pancreatic cancer metastasis (2017), Oncotarget, 8, 7691-7709 .

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Application

Application	Comment	Organism
medicine	patients with pancreatic ductal adenocarcinoma expressing higher enzyme levels present poorer prognosis compared to other groups	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R	Homo sapiens	-	CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15907	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
PANC-1 cell	-	Homo sapiens	-
pancreatic ductal adenocarcinoma cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R	-	Homo sapiens	CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R	-	?

Synonyms

Synonyms	Comment	Organism
beta-galactoside alpha2,6-sialyltransferase 1	-	Homo sapiens
ST6Gal	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	fructose substitution upregulates the enzyme activity	up

General Information

General Information	Comment	Organism
malfunction	enzyme knockdown is sufficient to inhibit pancreatic cancer metastasis in pancreatic ductal adenocarcinoma	Homo sapiens
physiological function	the enzyme regulates the invasiveness of pancreatic ductal adenocarcinomas in a fructose-responsive manner	Homo sapiens

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Release 2023.1 (January 2023)