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Literature summary for 2.4.3.1 extracted from

  • Garnham, R.; Scott, E.; Livermore, K.; Munkley, J.
    ST6GAL1 A key player in cancer (2019), Oncol. Lett., 18, 983-989 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.3.1

Application

Application Comment Organism
medicine the enzyme is associated with reduced recurrence-free intervals and a poorer overall survival in ovarian, prostate and pancreatic cancer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P15907
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetyl-beta-neuraminate + recombinant alpha-1-antitrypsin
-
 Homo sapiens CMP + ?
-
 ?

Synonyms

Synonyms Comment Organism
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
-
 Homo sapiens
ST6Gal1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is downregulated in bladder cancer down
Homo sapiens the enzyme is upregulated in numerous types of cancer (including cervical, colon, gastric, glioma, leukemia, liver, melanoma, pancreatic, prostate, breast and ovarian cancer) up

General Information

General Information Comment Organism
physiological function in the hallmarks of cancer, the enzyme plays a role in resisting cell death, inducing angiogenesis, evading growth suppressors, activating invasion and metastasis, avoiding immune destruction, enabling replicative immortality, sustained proliferative signalling, tumor promoting inflammations, deregulating cellular energetics, and genome instability and mutation Homo sapiens